PMID: 11326543May 1, 2001Paper

Corticosteroid receptor and stress

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
Mayumi Nishi, Mitsuhiro Kawata

Abstract

Adrenal corticosteroids readily enter the brain and exert markedly diverse effects, such as stress response of the target neural cells. These effects are regulated via two receptor systems, the mineralocorticoid receptor (MR; type I corticosteroid receptor) and the glucocorticoid receptor (GR; type II corticosteroid receptor), both of which are ligand-dependent transcription factors. MR is localized mainly in the hippocampus, and GR is distributed throughout the brain. MR and GR, however, are highly colocalized in the hippocampus, which is a target of the stress hormone and an especially plastic and vulnerable region of the brain. MR has a high affinity for corticosterone/cortisol, a common endogenous ligand for MR and GR, and is extensively bound at low levels of circulating corticosterone/cortisol. GR has a lower affinity and is extensively bound at high levels of circulating corticosterone/cortisol. These findings suggest that MR plays major roles under physiological conditions, whereas GR is mainly effective at high concentrations of corticosterone/cortisol, such as stressful conditions. The interactions of MR and GR in the hippocampal regions could be important for regulating stress response in the brain.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.