Corticosteroid regulation of gonadotropin and prolactin secretion in the rat

Endocrinology
D W BrannV B Mahesh

Abstract

The purpose of this study was to determine if glucocorticoids had any direct effects on the release of gonadotropin. In estrogen-primed ovariectomized immature rats, triamcinolone acetonide and deoxycorticosterone (1 mg/kg BW) caused a surge in both serum LH and FSH levels. Dexamethasone treatment (0.05 mg/kg BW) resulted in a highly significant selective release of FSH. Cortisol (1 mg/kg BW) suppressed serum FSH levels. A systematic dose-response study showed that triamcinolone acetonide significantly released LH and FSH and suppressed PRL at all doses tested (range, 0.25-4 mg/kg BW). Deoxycorticosterone was not as potent as triamcinolone acetonide and only doses greater than 0.8-1 mg/kg BW significantly released LH and FSH. Dexamethasone selectively released FSH at low doses (0.01, 0.02, 0.05, and 0.1 mg/kg BW) and inhibited LH at higher doses (0.5 and 1.0 mg/kg BW). A single low dose of dexamethasone (0.02 mg/kg BW) was found to significantly release LH. With respect to PRL secretion, a biphasic effect of dexamethasone was observed in that the lowest dose (0.01 mg/kg BW) stimulated PRL release while the highest dose (1.0 mg/kg BW) significantly inhibited PRL release. Triamicolone acetonide and deoxycorticosterone were found ...Continue Reading

Citations

Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·C Putnam-RobertsV B Mahesh
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·V B Mahesh, D W Brann
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·M BicíkováL Stárka
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·D W Brann, V B Mahesh
Jan 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·V B MaheshL B Hendry
Feb 28, 2003·General and Comparative Endocrinology·Katrina G Salvante, Tony D Williams
Dec 14, 2002·Brain Research. Developmental Brain Research·Hyun Joon KimWan Sung Choi
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·G ValliN Srinivasan
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
May 28, 2010·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Feb 10, 2009·The Journal of Reproduction and Development·L Christie Rockwell, Robert D Koos
Apr 5, 2005·Journal of Basic and Clinical Physiology and Pharmacology·S A NevagiL S Doddamani
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Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Tatiana ManciniAndrea Giustina
Dec 26, 2001·Biology of Reproduction·Francisco GaytánJosé Eugenio Sánchez-Criado
Oct 4, 2000·Physiological Reviews·M E FreemanG Nagy

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