PMID: 2106139Mar 1, 1990Paper

Corticosteroid regulation of gonadotropin secretion and induction of ovulation in the rat

Proceedings of the Society for Experimental Biology and Medicine
D W BrannV B Mahesh

Abstract

In the human polycystic ovarian syndrome, glucocorticoids have been demonstrated to have beneficial effects in inducing ovulation in a number of cases. These beneficial effects were assumed to be due to suppression of adrenal overproduction of androgens. However, the possibility exists that glucocorticoids may directly regulate gonadotropin secretion and thereby improve menstrual rhythm and ovulatory activity. Herein, we report that the corticoid, deoxycorticosterone, and the synthetic glucocorticoid, triamcinolone acetonide, like progesterone (P4), are able to induce luteinizing hormone and follicle-stimulating hormone surges and facilitate ovulation in the pregnant mare serum gonadotropin-primed rat. This effect is not shared by cortisol. Prolactin release was also stimulated by deoxycorticosterone, cortisol, and progesterone, but not by triamcinolone acetonide. Similar to progesterone, triamcinolone acetonide and deoxycorticosterone administration caused a loss of fluid retention in the uterus. This effect of triamcinolone acetonide and deoxycorticosterone may be related to progesterone action as opposed to anti-inflammatory action since cortisol had no effect on uterine fluid retention. These findings raise the possibility ...Continue Reading

Citations

Aug 1, 1992·Pharmacology, Biochemistry, and Behavior·C A Frye, J F DeBold
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·V B Mahesh, D W Brann
Aug 5, 2000·The Journal of Steroid Biochemistry and Molecular Biology·G ValliN Srinivasan
Oct 27, 2011·American Journal of Physiology. Endocrinology and Metabolism·Virendra B Mahesh
May 28, 2010·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Sep 16, 2019·Molecular and Cellular Endocrinology·Richard B McCoshAlexander S Kauffman

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