PMID: 8969897Nov 1, 1996Paper

Corticosteroid synthesis in the central nervous system

Endocrine Research
C E Gomez-SanchezE P Gomez-Sanchez

Abstract

The possibility that adrenocorticosteroids might be synthesized in the central nervous system was assessed by RT-PCR using primers for the CYP11B1 gene which codes for 11 beta-hydroxylase, the enzyme responsible for corticosterone and cortisol formation in the zona fasciculata, incubation of minces of several areas of the brain with 3H-DOC and measuring steroid metabolites, and determining the effect of the intracerebroventricular infusion of the 11 beta-hydroxylase mechanism-based inhibitor 19-ethynyldeoxycorticosterone upon the salt-induced increase in blood pressure in SS/jr rats. Significant, though small relative to the adrenal, amounts of mRNA for 11 beta-hydroxylase was found in the aorta, cerebrum, cerebellum, hippocampus, hypothalamus and amygdala, but not in the heart. Brain minces converted 3H-DOC to corticosterone and 11-dehydrocorticosterone to a greater degree than to 18-OH-DOC. The effect of 19-ethynyldeoxycorticosterone was dose dependent, with the lower doses preventing salt-induced hypertension and the higher doses having no effect or increasing the blood pressure.

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Citations

Mar 3, 2004·Annals of the New York Academy of Sciences·Birgit Stoffel-Wagner
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Elise P Gomez-Sanchez
Oct 14, 2004·American Journal of Physiology. Endocrinology and Metabolism·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Jan 2, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Bing S HuangFrans H H Leenen
Oct 20, 2009·Experimental Physiology·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Feb 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Scott M MacKenzieEleanor Davies
Dec 15, 2004·The Journal of Experimental Medicine·Igor CimaThomas Brunner
Oct 2, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elise P Gomez-SanchezNaveed Ahmad
Aug 4, 2009·Experimental Physiology·Elise P Gomez-Sanchez
Aug 25, 2009·Endocrinology·Celso E Gomez-Sanchez
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Bing S HuangFrans H H Leenen
Aug 11, 2011·PloS One·Shimpei HigoSuguru Kawato
Jan 2, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian ChenElise Gomez-Sanchez
May 17, 2001·Current Hypertension Reports·C E Gomez-Sanchez, E P Gomez-Sanchez
Nov 28, 2007·Endocrinology·Elise P Gomez-SanchezCelso E Gomez-Sanchez
Jun 26, 2003·Clinical and Experimental Pharmacology & Physiology·Eleanor Davies, Scott M MacKenzie
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Matthew D TavesKiran K Soma
Jul 1, 2016·Journal of Molecular Endocrinology·Aurelie Nguyen Dinh CatRhian M Touyz
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Joel C Geerling, Arthur D Loewy
Aug 1, 2018·International Journal of Molecular Sciences·Kalina Duszka, Walter Wahli
May 19, 2011·Clinical and Experimental Pharmacology & Physiology·Kenji OkiCelso E Gomez-Sanchez
Jan 7, 2015·Steroids·Guillaume BouguenBenjamin Bertin
Nov 14, 1997·Frontiers in Neuroendocrinology·E P Gómez-Sánchez
May 9, 2002·Molecular and Cellular Endocrinology·Lu YuElise P Gomez-Sanchez

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