Corticosteroid therapy for nephrotic syndrome in children

The Cochrane Database of Systematic Reviews
Deirdre HahnJonathan C Craig

Abstract

In nephrotic syndrome protein leaks from the blood to the urine through the glomeruli resulting in hypoproteinaemia and generalised oedema. While most children with nephrotic syndrome respond to corticosteroids, 80% experience a relapsing course. Corticosteroids have reduced the mortality rate to around 3%. However corticosteroids have well recognised potentially serious adverse effects such as obesity, poor growth, hypertension, diabetes mellitus, osteoporosis and behavioural disturbances. This is an update of a review first published in 2000 and updated in 2003, 2005 and 2007. The aim of this review was to assess the benefits and harms of different corticosteroid regimens in children with steroid-sensitive nephrotic syndrome (SSNS). The benefits and harms of therapy were studied in two groups of children 1) children in their initial episode of SSNS, and 2) children who experience a relapsing course of SSNS. We searched the Cochrane Renal Group's Specialised Register to 26 February 2015 through contact with the Trials Search Co-ordinator using search terms relevant to this review. Randomised controlled trials (RCTs) performed in children (three months to 18 years) in their initial or subsequent episode of SSNS, comparing diffe...Continue Reading

Associated Clinical Trials

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Citations

Oct 7, 2015·Frontiers in Pediatrics·Pietro A A Canetta, Jai Radhakrishnan
Jun 16, 2016·Frontiers in Pediatrics·Abhijeet Pal, Frederick Kaskel
Jun 4, 2019·Health Technology Assessment : HTA·Nicholas Ja WebbNatalie J Ives
Aug 21, 2015·Archives of Disease in Childhood·Nicholas LarkinsElisabeth Hodson
Jun 6, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Georges DeschênesJulien Hogan
Apr 29, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Elisabeth M HodsonJonathan C Craig
May 30, 2017·BioMed Research International·Eva Königshausen, Lorenz Sellin
Feb 21, 2019·Experimental and Therapeutic Medicine·Dongdong WangZhiping Li
Apr 17, 2020·The Cochrane Database of Systematic Reviews·Nicholas G LarkinsElisabeth M Hodson
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Sep 9, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Menka YadavArvind Bagga
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Jun 7, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Rasmus EhrenUNKNOWN German Society for Pediatric Nephrology

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