Corticosteroid therapy in ulcerative colitis: Clinical response and predictors

World Journal of Gastroenterology : WJG
Jin LiBing Xia

Abstract

To evaluate clinical response to initial corticosteroid (CS) treatment in Chinese ulcerative colitis patients (UC) and identify predictors of clinical response. Four hundred and twenty-three UC patients who were initially treated with oral or intravenous CS from 2007 to 2011 were retrospectively reviewed at eight inflammatory bowel disease centers in China, and 101 consecutive cases with one-year follow-up were analyzed further for clinical response and predictors. Short-term outcomes within one month were classified as primary response and primary non-response. Long-term outcomes within one year were classified as prolonged CS response, CS dependence and secondary non-response. CS refractoriness included primary and secondary non-response. Multivariate analyses were performed to identify predictors associated with clinical response. Within one month, 95.0% and 5.0% of the cases were classified into primary response and non-response, respectively. Within one year, 41.6% of cases were assessed as prolonged CS response, while 49.5% as CS dependence and 4.0% as secondary non-response. The rate of CS refractoriness was 8.9%, while the cumulative rate of surgery was 6.9% within one year. After multivariate analysis of all the variab...Continue Reading

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Citations

Oct 26, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Fan WangQiu Zhao
Jul 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ling ZhaoZhao-Xiang Bian
Jun 19, 2018·Expert Review of Gastroenterology & Hepatology·Eva Barreiro-AlonsoManuel Sánchez
May 11, 2017·Molecular Medicine Reports·Li-Hong HuBing-Rong Liu

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