Corticosteroids and perinatal hypoxic-ischemic brain injury

Drug Discovery Today
Katherine R Concepcion, Lubo Zhang

Abstract

Perinatal hypoxic-ischemic (HI) brain injury is the major cause of neonatal mortality and severe long-term neurological morbidity. Yet, the effective therapeutic interventions currently available are extremely limited. Corticosteroids act on both mineralocorticoid (MR) and glucocorticoid (GR) receptors and modulate inflammation and apoptosis in the brain. Neuroinflammatory response to acute cerebral HI is a major contributor to the pathophysiology of perinatal brain injury. Here, we give an overview of current knowledge of corticosteroid-mediated modulations of inflammation and apoptosis in the neonatal brain, focusing on key regulatory cells of the innate and adaptive immune response. In addition, we provide new insights into targets of MR and GR in potential therapeutic strategies that could be beneficial for the treatment of infants with HI brain injury.

Citations

Oct 23, 2019·Molecular Informatics·Hiroaki IwataYasushi Okuno
Aug 22, 2018·International Journal of Molecular Sciences·Yong LiLubo Zhang
Mar 15, 2020·Cellular and Molecular Neurobiology·Rafael Bandeira FabresLuciano Stürmer de Fraga
Jul 19, 2019·International Journal of Molecular Sciences·Katherine R Knox-ConcepcionLubo Zhang
Mar 7, 2020·Translational Stroke Research·Svetlana AltamentovaMichael G Fehlings
Jan 20, 2021·Physiological Research·A FrajewickiV Riljak
Aug 4, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ammir Yacoub HelouMarucia Chacur

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.