Corticosterone, brain mineralocorticoid receptors (MRs) and the activity of the hypothalamic-pituitary-adrenal (HPA) axis: the Lewis rat as an example of increased central MR capacity and a hyporesponsive HPA axis

Psychoneuroendocrinology
M S OitzlE R de Kloet

Abstract

In this study we report a series of differences in brain and peripheral elements regulating the hypothalamic-pituitary-adrenal (HPA) axis between male LEW and Wistar rats. We found: (i) differential properties of mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) in the brain (hippocampus, hypothalamus) and pituitary: LEW rats displayed an increased capacity of MRs in the hippocampus and hypothalamus and a decreased capacity of glucocorticoid receptors GRs in the pituitary. The binding affinity (Kd) for MRs and GRs in the hippocampus was comparable. (ii) Lower concentrations of corticotropin releasing hormone (CRH) mRNA were detected in the nucleus paraventricularis of the hypothalamus of LEW rats. (iii) Adrenal weight was similar in LEW and Wistar rats; however, LEW rats had about 30% less adrenocortical cells. Subjecting adrenocortical cells to increasing doses of ACTH1-24 in vitro resulted in about a 60% smaller release of corticosterone in LEW rats. (iv) LEW rats escaped dexamethasone suppression showing increased basal levels of endogenous ACTH, but responded with a comparable release of corticosterone to the IV injection of 5 ng ACTH1-24. (v) LEW rats responded to a variety of stimuli: adrenalectomy unde...Continue Reading

References

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Citations

Aug 1, 1993·Cellular and Molecular Neurobiology·E R de KloetM Joëls
May 18, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Man LiYuxiu Shi
Jun 1, 2007·Brain Imaging and Behavior·Nicole Y L OeiSerge A R B Rombouts
Oct 18, 2000·European Journal of Pharmacology·J M ReulA C Linthorst
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Feb 13, 2001·Journal of Psychiatric Research·P D PatelA F Schatzberg
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·T StöhrC R Pryce
Nov 24, 2001·Behavioural Brain Research·S J Lupien, M Lepage
Jan 31, 2002·Psychoneuroendocrinology·Sonia J LupienN P V Nair
Jan 1, 1997·Trends in Endocrinology and Metabolism : TEM·E R De KloetM Joëls
Aug 1, 2002·Acta Neuropsychiatrica·Er de Kloet
Sep 15, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Benjamin H FloresAlan F Schatzberg
May 3, 2000·Journal of Neuroendocrinology·J HallerM R Kruk
Jan 6, 1999·The European Journal of Neuroscience·M S OitzlE R de Kloet
Apr 12, 2000·Kidney International·E R de KloetW de Jong
Dec 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Stefan BergerGünther Schütz
Jan 5, 2001·Alcoholism, Clinical and Experimental Research·D D RasmussenC W Wilkinson
Jun 20, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Francesco NodariTimothy E Holy
Jul 26, 2011·Behavioural Brain Research·Ksenia Z MeyzaJolanta Zagrodzka
May 19, 2009·Hormones and Behavior·V BrinksM S Oitzl
Dec 2, 2008·Physiology & Behavior·Greta AgrenThomas Lundeberg

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