Corticosterone, choline acetyltransferase and noradrenaline levels in olfactory bulbectomized rats in relation to changes in passive avoidance acquisition and open field activity

Physiology & Behavior
C L BroekkampA M Van Delft

Abstract

Consequences of olfactory bulbectomy in two behavioural situations, passive avoidance acquisition and activity in a brightly lit open field, were measured in the same animals for which data on four biochemical measures were also obtained. The biochemical measurements were on plasma corticosterone levels, noradrenaline (NA) levels in the midbrain and amygdala + pyriform cortex and the choline acetyltransferase (CAT) levels in the olfactory tubercle. Experimental variation in age groups of rats (7 weeks and 3 months) and in post-bulbectomy periods (1, 2 and 4 weeks) was made. The deficit in passive avoidance as a consequence of olfactory bulbectomy was evident in all groups of young animals and in older animals one and two weeks post-bulbectomy but not in older animals four weeks after bulbectomy. An increase in open field activity was similarly observed in all groups except in the older animals four weeks after bulbectomy. In contrast to reports by other investigators the basal plasma corticosterone levels were not increased in bulbectomized animals nor did we observe any diminution of NA levels in the amygdala (+ pyriform cortex). CAT levels were slightly increased in older animals two weeks after bulbectomy. The absence of a c...Continue Reading

References

Mar 1, 1979·Pharmacology, Biochemistry, and Behavior·K D CairncrossH Schnieden
Jul 1, 1979·Psychoneuroendocrinology·K D CairncrossA F Wren
Aug 1, 1977·British Journal of Pharmacology·H van RiezenA F Wren
May 1, 1975·Pharmacology, Biochemistry, and Behavior·K D CairncrossJ R Bassett
May 1, 1971·Physiology & Behavior·G E Brown, N R Remley
Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·S M Jancsàr, B E Leonard
Nov 1, 1983·Psychiatry Research·S J Nasr, R D Gibbons
Nov 1, 1980·Pharmacology, Biochemistry, and Behavior·C L BroekkampK G LLoyd
Sep 1, 1981·Pharmacology, Biochemistry, and Behavior·L NoreikaJ Liebman
Nov 1, 1980·Brain Research Bulletin·J A TonnaerV J Nickolson

❮ Previous
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Citations

Aug 1, 1994·Neuropharmacology·J P Kelly, B E Leonard
May 1, 1996·Pharmacology, Biochemistry, and Behavior·B E Leonard, C Song
Jan 1, 1990·Pharmacology & Therapeutics·H van Riezen, B E Leonard
Apr 3, 2004·Physiology & Behavior·Cher V MasiniGaylen L Edwards
Dec 13, 2000·Pharmacology, Biochemistry, and Behavior·H S StockM A Wilson
Dec 22, 2000·Pharmacology, Biochemistry, and Behavior·S D Primeaux, P V Holmes
Jun 23, 2001·Pharmacology, Biochemistry, and Behavior·G Bissette
Jan 1, 1997·Pharmacology & Therapeutics·J P KellyB E Leonard
Apr 30, 2005·Biological Psychiatry·Hiske M van der SteltHerman G M Westenberg
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Cai Song, Brian E Leonard
Jun 1, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ti-Fei Yuan, Burton M Slotnick
Dec 3, 2014·European Journal of Pharmacology·Hendrikus HendriksenRonald S Oosting
Jan 8, 2011·Neurochemistry International·Ivan SkelinMirko Diksic
Feb 1, 1988·The International Journal of Neuroscience·J A Jesberger, J S Richardson
Jan 3, 2020·Behavioural Pharmacology·Shengying PanHaiyan He
Jul 18, 2002·Behavioural Pharmacology·P Willner, P J Mitchell
Oct 19, 2017·Biochemistry. Biokhimii︠a︡·N V GulyaevaN A Stefanova
Sep 11, 2012·Pharmacology, Biochemistry, and Behavior·Daniele G MachadoAna Lúcia S Rodrigues
Aug 1, 1990·Brain Research Bulletin·F J Arnold, L R Meyerson

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