Corticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding

American Journal of Physiology. Endocrinology and Metabolism
Martine DuclosDenis Richard

Abstract

The obese Zucker (fa/fa) rat is characterized by hyperphagia, hyperinsulinemia, an increase in fat deposition, and a hyperactivity in the hypothalamic-pituitary-adrenal (HPA) axis. The HPA axis in fa/fa rats is hypersensitive to stressful experimental conditions. Food deprivation even leads to a stress reaction in obese fa/fa rats. The present study was conducted to investigate the role of corticosterone in obese rats on the basal, fasting, and postprandial metabolic rate as well as on the central expression of the thyrotropin-releasing hormone (TRH) in these conditions. In addition, the study was aimed at clarifying whether the high levels of corticosterone in obese rats are responsible for the induction of the stress reaction to food deprivation in these animals. The present results demonstrate that whole body fat oxidation and postprandial metabolic responses in obese Zucker rats were improved by adrenalectomy (ADX). At the level of the central nervous system, ADX reversed a decrease in TRH mRNA expression in the paraventricular hypothalamus (PVH) detected in fasting animals. Considering all feeding conditions, the obese rats demonstrated lower TRH mRNA levels compared with lean animals. ADX resulted in an enhanced postprand...Continue Reading

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Citations

Jan 8, 2015·The Journal of Endocrinology·Patricia Joseph-BravoJean-Louis Charli
May 16, 2006·Peptides·Aleksandra Vicentic
Sep 20, 2006·Progress in Neurobiology·Norman PecoraroSusan F Akana
May 5, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christian RoyKatherine Cianflone
Jun 28, 2007·American Journal of Physiology. Endocrinology and Metabolism·Helge MüllerWalter Raasch
May 1, 2021·International Journal of Molecular Sciences·Agnieszka Siomek-GoreckaDamian Czarnecki

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