PMID: 2498878May 1, 1989Paper

Corticosterone differentially regulates the expression of Gs alpha and Gi alpha messenger RNA and protein in rat cerebral cortex

Proceedings of the National Academy of Sciences of the United States of America
N SaitoE J Nestler

Abstract

The possibility that glucocorticoids regulate specific guanine nucleotide binding regulatory proteins (G proteins) was investigated in rat cerebral cortex. Corticosterone was administered to normal and bilaterally adrenalectomized rats, and hormone regulation of individual G-protein subunits was investigated in cerebral cortex in three ways: (i) immunoblot analysis of subunit protein, (ii) hybridization blot analysis of subunit mRNA, and (iii) ADP-ribosylation analysis of stimulatory G protein (Gs alpha) subunits. Chronic (7 days) corticosterone administration to normal rats increased levels of Gs alpha immunoreactivity, mRNA, and ADP-ribosylation but decreased levels of inhibitory G protein (Gi alpha) mRNA and tended to decrease levels of Gi alpha immunoreactivity. In contrast, levels of Go alpha and G beta immunoreactivity and mRNA were not influenced by corticosterone treatment. In adrenalectomized rats, corticosterone treatment produced a 25-50% increase in the levels of Gs alpha immunoreactivity, mRNA, and ADP-ribosylation, whereas the hormone produced a 20-35% decrease in the levels of Gi alpha immunoreactivity and mRNA. Adrenalectomy, without corticosterone replacement, produced the opposite effects on Gs alpha and Gi al...Continue Reading

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Citations

Jan 1, 1991·Journal of Neural Transmission. General Section·K P Lesch, B Lerer
Jan 15, 1999·Molecular Neurobiology·M Joëls, E Vreugdenhil
Aug 19, 1991·Brain Research. Developmental Brain Research·L T YoungS J Kish
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Aug 12, 1998·The Journal of Steroid Biochemistry and Molecular Biology·A F De NicolaE R de Kloet
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S F ColinE J Nestler

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