Corticosterone increases spike-wave discharges in a dose- and time-dependent manner in WAG/Rij rats

Pharmacology, Biochemistry, and Behavior
Ulrich Schridde, G van Luijtelaar

Abstract

Corticosteroids mediate seizure activity in different epilepsy models or epilepsies. However, for childhood absence epilepsy, a nonconvulsive type of epilepsy, direct evidence for corticosteroid seizure modulation is lacking. Thus, in the present study, we analysed the acute systemic effects of different doses of the corticosteroid corticosterone on seizure activity in a well-validated animal model of childhood absence epilepsy, the WAG/Rij rat. We found a time- and dose-dependent increase in the number of spike-wave discharges (SWD) in the EEG, with 500 microg/kg of corticosterone causing a 327% increase in discharges compared to baseline 15-30 min after administration. No treatment effects were found on mean duration of SWD and behavior. Our data indicate that corticosterone in a physiologically relevant dose can aggravate absence seizures in a rapid but transient way. Regarding the time course of the effect, we suggest that corticosterone is acting nongenomically, possibly via a temporary increase of excitatory amino acids.

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Citations

Nov 16, 2010·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Nikki T Sawyer, Andrew Escayg
Dec 5, 2008·Epilepsia·Marian Joëls
Aug 14, 2009·Epilepsia·Karine Yu SarkisovaGilles van Luijtelaar
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Jan 29, 2016·Advanced Pharmaceutical Bulletin·Ghazaleh Ghamkhari NejadMina Sadighi Alvandi
Feb 7, 2007·Neuroscience Letters·Elena A Tolmacheva, Gilles van Luijtelaar
Jul 6, 2006·The European Journal of Neuroscience·Ulrich SchriddeGilles van Luijtelaar
Mar 15, 2005·Physiology & Behavior·Ulrich Schridde, Gilles van Luijtelaar
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Oct 20, 2009·Epilepsy & Behavior : E&B·Ricardo M AridaEsper A Cavalheiro

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