Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus

Neuroscience Letters
A R LittleJ P O'Callaghan

Abstract

Expression of the chemokine (C-C motif) ligand 2 (CCL2), also known as, monocyte chemoattractant protein (MCP)-1, increases in response to disease-, trauma-, or toxicant-induced damage to the central nervous system (CNS). In the periphery, endogenous and exogenous glucocorticoids are known to suppress CCL2 expression associated with inflammatory conditions. However, such actions of glucocorticoids on CCL2 expression in the CNS remain unknown. Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats. An immunosuppressive regimen of CORT did not alter the mRNA expression of CCL2 or its receptors in the hippocampus. ADX, however, markedly increased the expression of CCL2 and CCR2 mRNAs in the hippocampus, while CORT replacement reversed the effects of ADX on CCL2 gene expression. Hippocampal damage resulting from systemic administration of the organometallic neurotoxicant, TMT, was associated with microglial activation, as evidenced by enhanced expression of microglial markers integrin alphaM (CD11b) and F4/80, as well as, microglia-associated factors, ...Continue Reading

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Citations

Dec 25, 2010·Neurochemical Research·Bárbara TagliariAngela T S Wyse
Feb 6, 2010·Journal of Neurochemistry·Jose L M MadrigalJuan C Leza
Feb 24, 2015·Psychoneuroendocrinology·Christina L Nemeth, Gretchen N Neigh
Jan 24, 2018·Frontiers in Endocrinology·Igor Ferraz da SilvaLívia Carla de Melo Rodrigues

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