Corticotrophin-releasing factor gene transcription is directly activated after deprivation of glucocorticoids in hypothalamic cells

Journal of Neuroendocrinology
K KageyamaT Suda

Abstract

Corticotrophin-releasing factor (CRF) plays a central role in controlling the hypothalamic-pituitary-adrenal axis during stressful periods. CRF neurones are activated in the hypothalamic paraventricular nucleus (PVN) in response to stress, whereas the activated CRF neurones in the PVN are suppressed by glucocorticoids. Glucocorticoids may act directly on CRF neurones because glucocorticoid receptors are expressed highly on these neurones in the PVN. CRF expression levels in the PVN are also increased by adrenalectomy in vivo. The signalling pathways involved in the control of CRF gene transcription in the hypothalamus when negative feedback by glucocorticoids after adrenalectomy is lost remain undetermined. We investigated whether CRF gene transcription is regulated by both glucocorticoids and glucocorticoid withdrawal in hypothalamic cells. The present study demonstrates that CRF gene transcription activity and mRNA levels in the hypothalamic 4B cells were not modulated by incubation with dexamethasone for a short 2-h period, although they were stimulated by incubation for longer than 5 h. CRF gene transcription activity and mRNA levels were increased after 2 h of dexamethasone deprivation. The cAMP-response element (CRE) on t...Continue Reading

References

Jan 1, 1996·Critical Reviews in Neurobiology·J P HermanW E Cullinan
May 3, 2002·The Journal of Biological Chemistry·Meng-Min LiuPeter J Kushner
Sep 21, 2002·Molecular and Cellular Endocrinology·Bruce R KingRichard C Nicholson
Nov 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William J Schouler MillerRosalie M Uht
Feb 28, 2009·Journal of Endocrinological Investigation·K KageyamaT Suda
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Servane LachizeOnno C Meijer

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Citations

Mar 29, 2011·Stress : the International Journal on the Biology of Stress·Kazunori KageyamaToshihiro Suda
Jun 2, 2012·Experimental Cell Research·Yang Guo, Pingfu Feng
Apr 15, 2014·Journal of Neuroendocrinology·E T UchoaM B C de Sousa
Sep 29, 2012·Behavioural Brain Research·Andiara E FreitasAna Lúcia S Rodrigues
Sep 26, 2013·Molecular Endocrinology·Andrew N EvansGreti Aguilera

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