Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats

Psychoneuroendocrinology
Hongxin DongJohn G Csernansky

Abstract

Mounting evidence suggests that chronic stress can alter brain structure and function and promote the development of neuropsychiatric disorders, such as depression and Alzheimer's disease. Although the results of several studies have indicated that aged brains are more vulnerable to chronic stress, it remains unknown whether antagonists of a key stress regulator, the corticotrophin releasing factor receptor 1 (CRF1), can prevent stress-induced anxiety and memory deficits in animal models. In this study, we evaluated the potential benefits of two CRF1 antagonists, R121919 and antalarmin, for preventing stress-induced anxiety-related behavioral and memory deficits and neurodegeneration in aged rats. We stressed rats using isolation-restraint for 3 months starting from the 18 months of age. Subsets of animals were administrated either R121919 or antalarmin through food chow for 3 months, followed by a series of behavioral, biochemical and morphological analyses. We found that stressed aged rats displayed body weight losses and increased corticosterone levels, as well as anxiety-related behaviors and memory deficits. Additionally, chronic stress induced a loss of cortical dendritic spines and synapses. However, R121919 and antalarm...Continue Reading

References

Sep 1, 1992·Behavioral and Neural Biology·M D LindnerC P VanderMaelen
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·E O JohnsonP W Gold
Sep 15, 1990·Annals of Internal Medicine·M C GeokasP S Timiras
Jan 1, 1988·Advances in Experimental Medicine and Biology·E B De Souza, G Battaglia
Dec 26, 2001·Nature Reviews. Neuroscience·H Hering, M Sheng
Jun 24, 2004·Expert Opinion on Investigational Drugs·Eric P Zorrilla, George F Koob
Jul 13, 2006·Journal of Aging and Health·Thomas A GlassLisa F Berkman
Aug 2, 2006·Reviews in the Neurosciences·Luis Orozco-CabalJoel P Gallagher
Nov 18, 2006·The Journal of Comparative Neurology·Hongxin DongJohn G Csernansky
Dec 8, 2006·The American Journal of Psychiatry·John G CsernanskyJohn C Morris
Jun 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jae-Eun KangDavid M Holtzman
Aug 22, 2007·Neuroscience Letters·Simone MarcuzzoAlberto A Rasia-Filho
Mar 18, 2008·European Journal of Pharmacology·Joel P GallagherPatricia Shinnick-Gallagher
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hongxin DongJohn G Csernansky
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Sep 4, 2009·Trends in Cognitive Sciences·John T Cacioppo, Louise C Hawkley
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Avis Brennan HainsAmy F T Arnsten
Mar 9, 2010·Drug Discovery Today·Eric P Zorrilla, George F Koob
May 4, 2010·Behavioural Brain Research·Dawn L MerrettGerlinde A Metz
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Erik B BlossJohn H Morrison
May 21, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan C HolmesJoyce L W Yau
May 12, 2011·The Journal of Pharmacology and Experimental Therapeutics·M HoriguchiH Y Meltzer
Dec 14, 2011·Australian and New Zealand Journal of Public Health·Duncan Boldy, Linda Grenade
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Robert A RissmanPaul E Sawchenko
Jun 29, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Masakuni HoriguchiHerbert Y Meltzer
Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew SteptoeJane Wardle
Jan 21, 2014·Neurobiology of Aging·Dóra RévészBrenda W J H Penninx
Feb 28, 2014·Frontiers in Aging Neuroscience·Heather M BuechelEric M Blalock
Jun 14, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Mark S GreenbergRoger K Pitman
Aug 30, 2014·Current Topics in Behavioral Neurosciences·Mak Adam Daulatzai

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Citations

Oct 16, 2019·Frontiers in Aging Neuroscience·Geoffrey CanetLaurent Givalois
Jun 9, 2021·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Gabriele Cheiran PereiraGuilherme Vargas Bochi

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