Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells

The Journal of Clinical Endocrinology and Metabolism
J L ShifrenRobert B Jaffe

Abstract

The human adrenal cortex has a complex vasculature that is essential for growth, organ maintenance, and access of secreted hormones to the circulation. Growth and function of the adrenal cortex are regulated by corticotropin (ACTH), the actions of which are in part mediated by locally produced growth factors. As cortical growth and vascularization must increase in a coordinated manner, we hypothesized that ACTH also influences adrenal cortical angiogenesis by stimulating the local expression of specific angiogenic factors. Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific angiogenic peptide, the expression of which has been detected in adrenal cortical cells. Therefore, we examined the localization of VEGF expression in the midgestation (16-20 weeks) human fetal adrenal cortex and determined whether VEGF expression and secretion by isolated human fetal adrenal cortical cells are regulated by ACTH. By immunohistochemical analysis, strong cytoplasmic staining for VEGF was detected in scattered clusters of fetal zone (inner cortical compartment) cells. In contrast, cells in the outer, definitive zone of the cortex stained only weakly for VEGF. The predominant staining for VEGF in the fetal zone correl...Continue Reading

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Citations

Mar 28, 2008·The Journal of Clinical Endocrinology and Metabolism·Hitoshi IshimotoRobert B Jaffe
Oct 16, 2008·The Journal of Clinical Endocrinology and Metabolism·Ferdous M BarlaskarGary D Hammer
Feb 19, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Petra Kempná, Christa E Flück
Jul 23, 2003·The Korean Journal of Internal Medicine·Byung-Soo Kim, Michael S Goligorsky
Jan 18, 2020·Scientific Reports·Takashi YoshidaSusumu Tanaka

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