Corticotropin-releasing factor in the rat amygdala differentially influences sensory-discriminative and emotional-like pain response in peripheral neuropathy

The Journal of Pain : Official Journal of the American Pain Society
Nora BourbiaAntti Pertovaara

Abstract

The central nucleus of the amygdala (CeA) is involved in processing and regulation of pain. We determined whether amygdaloid corticotropin-releasing factor (CRF) contributes to pain modulation in the neuropathic rat. Emotional aspect of pain was assessed by an aversive place-conditioning test and sensory aspect of pain by determining monofilament-induced limb-withdrawal threshold. CRF₆₋₃₃ (an inhibitor of CRF-binding protein) or CRF₉₋₄₁, a nonselective CRF receptor antagonist, was microinjected to the left or right CeA or a control site in rats with spared nerve injury (SNI) or sham operation of the left hind limb. In SNI animals, CRF₆₋₃₃ in the left or right CeA, but not in a control site, attenuated emotional painlike behavior and increased sensory pain. In sham controls, CRF₆₋₃₃ in the right but not left CeA increased sensory aspect of pain, without influence on place-avoidance behavior. The effects induced by CRF₆₋₃₃ were reversed by CRF₉₋₄₁. The results indicate that endogenous CRF in the CeA, through action on CRF receptors, may differentially influence emotional and sensory aspects of pain in neuropathy. While the right CeA had a dominant role in modulation of pain-related responses in sham controls, left as well as righ...Continue Reading

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Citations

Feb 18, 2012·European Journal of Pain : EJP·T RouwetteK Vissers
Feb 9, 2011·Brain Research·William R LariviereAnna Maria Aloisi
Oct 8, 2013·Pharmacology, Biochemistry, and Behavior·A Vania ApkarianSoundar Regunathan
Jan 18, 2011·Brain Research·Amteshwar Singh Jaggi, Nirmal Singh
Apr 26, 2019·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Nora BourbiaPatrick M Nolan
Mar 20, 2020·Neuropharmacology·Volker NeugebauerFrank Porreca
Jun 20, 2018·Scandinavian Journal of Pain·Nora Bourbia, Antti Pertovaara

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