Corticotropin-releasing factor infusion in the bed nucleus of the stria terminalis of lactating mice alters maternal care and induces behavioural phenotypes in offspring

Scientific Reports
Kerstin Camile CreutzbergRodrigo Grassi-Oliveira

Abstract

The peripartum period is accompanied by numerous physiological and behavioural adaptations organised by the maternal brain. These changes are essential for adequate expression of maternal behaviour, thereby ensuring proper development of the offspring. The corticotropin-releasing factor (CRF) plays a key role in a variety of behaviours accompanying stress, anxiety, and depression. There is also evidence that CRF contributes to maladaptations during the peripartum period. We investigated the effects of CRF in the bed nucleus of the stria terminalis (BNST) of lactating mice during maternal care and analysed locomotor activity and anxiety-like behaviour in the offspring. The BNST has been implicated in anxiety behaviour and regulation of the stress response. The effects of intra-BNST CRF administration were compared with those induced by the limited bedding (LB) procedure, a model that produces altered maternal behaviour. BALB/cJ dams were exposed to five infusions of CRF or saline into the BNST in the first weeks after birth while the LB dams were exposed to limited nesting material from postnatal days (P) 2-9. Maternal behaviour was recorded in intercalated days, from P1-9. Offspring anxiety-like behaviour was assessed during ad...Continue Reading

References

Jan 1, 1993·Ciba Foundation Symposium·P E SawchenkoW Vale
Nov 24, 1999·Biological Psychiatry·G F Koob
Jul 26, 2002·The Psychiatric Clinics of North America·Martin H TeicherCarryl P Navalta
Feb 26, 2003·European Journal of Pharmacology·David L WalkerMichael Davis
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Oct 11, 2005·Trends in Neurosciences·Jay SchulkinJeffrey B Rosen
Nov 29, 2005·European Archives of Psychiatry and Clinical Neuroscience·Robert F AndaWayne H Giles
Dec 13, 2006·The European Journal of Neuroscience·Daniela Rüedi-BettschenChristopher R Pryce
Jun 21, 2008·Endocrinology·Courtney J RiceTallie Z Baram
Jul 8, 2010·Neurotoxicity Research·Eva M MarcoGiovanni Laviola
Feb 19, 2011·Frontiers in Behavioral Neuroscience·Isabelle C WeissIsabelle M Mansuy
Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·J Michael BowersMargaret M McCarthy
Apr 16, 2013·The European Journal of Neuroscience·Agnieszka ChocykKrzysztof Wędzony
Aug 13, 2013·Psychiatry Research·Raphael J BragaSamuel G Siris
Jan 24, 2014·Psychological Medicine·A J BaxterH A Whiteford
Jul 18, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stefanie M KlampflOliver J Bosch
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S N AveryJ U Blackford
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Saulo G TractenbergRodrigo Grassi-Oliveira
Feb 22, 2017·Psychoneuroendocrinology·Sara SantarelliMathias V Schmidt
Oct 19, 2017·Stress : the International Journal on the Biology of Stress·Rodrigo OrsoRodrigo Grassi-Oliveira

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BETA
environmental stress

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BioRender
GraphPad Prism
maze
SPSS

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