PMID: 6310414Sep 15, 1983

Corticotropin-releasing factor is a potent inhibitor of sexual receptivity in the female rat

D J SirinathsinghjiW Vale


Corticotropin-releasing factor (CRF), the recently characterized and synthesized 41-amino acid polypeptide isolated from ovine hypothalami, has been shown to be a potent stimulator of adenohypophyseal beta-endorphin and corticotropin (ACTH) secretion both in vitro and in vivo. In common with other regulatory peptides, CRF has also been demonstrated to possess extra-hypophysiotropic roles. Indeed, intracerebroventricularly (i.c.v.) administered CRF elicits several endocrine and behavioural responses compatible with the concept that this peptide could be a key signal in coordinating the organism's endocrine and behavioural responses to stressful and other adaptive stimuli. We now provide the first evidence for neurally placed CRF in the control of a specific hormone-dependent behavioural response and unequivocally demonstrate an extremely potent suppressive effect of CRF on sexual behaviour in the female rat when microinfused into the arcuate-ventromedial area of the hypothalamus (ARC-VMH) and the mesencephalic central grey (MCG).


Jul 1, 1979·The Journal of Clinical Investigation·J A DempseyD A Pelligrino
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M RubinsteinS Udenfriend
Sep 1, 1979·Canadian Journal of Biochemistry·M ChrétienN G Seidah
Dec 1, 1979·Hormones and Behavior·C A WilsonD Everard
Mar 29, 1979·Nature·G E Gillies, P J Lowry
Feb 15, 1979·The Journal of Comparative Neurology·M S KriegerD W Pfaff
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J SpiessW Vale
Jan 1, 1981·Peptides·C M TurkelsonM Shimizu
Oct 4, 1982·Life Sciences·J E Morley, A S Levine


Jan 1, 1993·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L T KnappS A Camper
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·F Holsboer
Jan 1, 1992·European Archives of Psychiatry and Clinical Neuroscience·E UrA Grossman
May 15, 1990·Biological Psychiatry·D D KrahnM J Majchrzak
Mar 31, 1987·Brain Research·Y Sakuma, T Akaishi
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·J D Caldwell, L G Clemens
Apr 1, 1989·Pharmacology, Biochemistry, and Behavior·J T WinslowT R Insel
Jan 1, 1989·Pharmacology, Biochemistry, and Behavior·T R Insel, C R Harbaugh
Jun 1, 1990·Pharmacology, Biochemistry, and Behavior·F SpadaroA J Dunn
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·M P IuratoR Bernardini
Jun 1, 1989·Psychiatry Research·M FavaM Hirsch
Apr 16, 1996·Psychiatry Research·W H Kaye
Apr 16, 1996·Psychiatry Research·J LicinioPhilip W Gold
Jul 1, 1985·Regulatory Peptides·T PappasY Taché
May 1, 1992·Peptides·J R GlowaPhilip W Gold
Jan 1, 1990·Neurochemistry International·J FriasE Ortega
Jan 1, 1986·Progress in Neuro-psychopharmacology & Biological Psychiatry·Philip W GoldGeorge P Chrousos
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·U von Bardeleben, F Holsboer
Jan 1, 1991·Progress in Neuro-psychopharmacology & Biological Psychiatry·J R GlowaPhilip W Gold
Jul 1, 1992·Progress in Neuro-psychopharmacology & Biological Psychiatry·J R GlowaPhilip W Gold
Feb 1, 1996·Progress in Neuro-psychopharmacology & Biological Psychiatry·M C MauriG Penati
Mar 1, 1988·Brain Research Bulletin·D A Haas, S R George
Jul 16, 2013·Progress in Neurobiology·A Argiolas, Maria Rosaria Melis
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Jan 5, 2002·Journal of Psychiatric Research·Marianne B Müller, Martin E Keck
Sep 6, 2002·Physiology & Behavior·Juli E Jones, George N Wade
Feb 20, 1998·Physiology & Behavior·S Retana-MarquezJ Velazquez-Moctezuma
Apr 2, 2003·Neuroscience and Biobehavioral Reviews·Angela J Grippo, Alan Kim Johnson
Jan 22, 2000·Neuroscience and Biobehavioral Reviews·A Argiolas
Mar 1, 1991·Baillière's Clinical Endocrinology and Metabolism·E Ur
Dec 17, 2009·Molecular Psychiatry·E B Binder, C B Nemeroff
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·T NakaneC S Hollander
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A MillanG Aguilera
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H J Lenz
Sep 13, 1994·Proceedings of the National Academy of Sciences of the United States of America·E PotterW Vale
Mar 22, 1996·Annals of the New York Academy of Sciences·M P Stenzel-PooreS C Heinrichs
Jul 21, 1998·Annals of the New York Academy of Sciences·A E CalogeroR D'Agata
Feb 17, 2000·Annals of the New York Academy of Sciences·G F Koob
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Tracy L Bale, W Vale
Mar 1, 1985·The Journal of Clinical Investigation·H J LenzM R Brown
Sep 16, 2003·Medicine and Science in Sports and Exercise·George N Wade, Juli E Jones
Aug 2, 2006·Reviews in the Neurosciences·Luis Orozco-CabalJoel P Gallagher
Apr 20, 2011·The Australian and New Zealand Journal of Psychiatry·Nicolas J C StapelbergIan Hamilton-Craig
Sep 21, 2002·Journal of Endocrinological Investigation·E ArvatE Ghigo
Jun 6, 2006·Asian Journal of Andrology·Shawky El-HaggarNagwa Roshdy
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L WongPhilip W Gold
Aug 5, 1998·Journal of Clinical Psychopharmacology·R I ShaderD J Greenblatt
Jan 1, 1990·American Journal of Obstetrics and Gynecology·A SasakiK Yoshinaga
Dec 21, 2012·Journal of Neuroendocrinology·M J DickensJ Balthazart
May 26, 2004·Physiology & Behavior·Jill E Schneider
Feb 1, 1986·Neuropeptides·J D CaldwellC A Pedersen
Aug 28, 1992·Brain Research·L P Kapcala, J A Dicke
Sep 20, 2006·Progress in Neurobiology·Norman PecoraroSusan F Akana
Jan 1, 1987·Annals of the New York Academy of Sciences·R C ThompsonE Herbert
Aug 1, 2006·Hormones and Behavior·Jill M Goldstein
Apr 29, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Cornelius SchüleGregor Laakmann
Aug 1, 1988·Biological Psychiatry·Philip W Gold
Aug 18, 1988·The New England Journal of Medicine·Philip W GoldGeorge P Chrousos
Jan 22, 1987·The New England Journal of Medicine
Jul 28, 1988·The New England Journal of Medicine·A L Taylor, L M Fishman
May 17, 1984·Nature·Z Wiesenfeld-Hallin, P Södersten
Jan 1, 1988·Journal of Psychopharmacology·B G CharltonI N Ferrier
Nov 6, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George N Wade, Juli E Jones
May 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Paul M PlotskyMichael J Meaney
Aug 1, 1997·The Journal of Clinical Endocrinology and Metabolism·D MichelsonPhilip W Gold
Jan 1, 2009·Stress : the International Journal on the Biology of Stress·Angela J Grippo, Alan Kim Johnson
Aug 20, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Juli E JonesGeorge N Wade
Apr 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patricia L SeymourGeorge N Wade
Jan 1, 1991·American Journal of Primatology·Elizabeth O JohnsonGeorge P Chrousos
Nov 1, 1988·Journal of Endocrinological Investigation·D NerozziG Frajese
Mar 22, 1996·Annals of the New York Academy of Sciences·D E GrigoriadisE B De Souze
Oct 1, 1990·Journal of Endocrinological Investigation·S Tsagarakis, A Grossman

Related Concepts

Aggressive Behavior
Corticotropin-Releasing Hormone
Organum Vasculosum Laminae Terminalis
Gonadorelin Hydrochloride
Midbrain Structure
Sexual Behavior, Animal

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.