Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1

F BerkenboschH Besedovsky


Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affects pituitary-adrenal activity is unknown. That the IL-1-induced pituitary-adrenal activation involves an increased secretion of corticotropin-releasing factor (CRF) is indicated by three lines of evidence. First, immunoneutralization of CRF markedly attenuated the IL-1-induced increase of ACTH blood levels. Second, after blockade of fast axonal transport in hypothalamic neurons by colchicine, IL-1 administration decreased the CRF immunostaining in the median eminence, indicating an enhanced release of CRF in response to IL-1. Third, IL-1 did not stimulate ACTH release from primary cultures of anterior pituitary cells. These data further support the notion of the existence of an immunoregulatory feedback circuit between the immune system and the brain.


Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H BesedovskyJ Müller
Jan 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D S Gross, J M Rothfeld
Nov 29, 1985·Science·B M WoloskiJ E Blalock
Nov 1, 1985·Peptides·M S AhmedC M Blatteis
Sep 1, 1985·Journal of Clinical Immunology·C A Dinarello
May 4, 1984·Science·J Axelrod, T D Reisine
May 1, 1980·The Histochemical Journal·J P KraehenbuhlG W Griffiths
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S B MizelS E Mergenhagen
Dec 1, 1981·Acta Endocrinologica·I BercziE Horvath
Feb 1, 1981·The Journal of Experimental Medicine·A L MaizelL B Lachman
Jan 1, 1982·Immunological Reviews·S B Mizel
Jul 1, 1982·Brain Research Bulletin·J Schipper, F J Tilders
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss

❮ Previous
Next ❯


Jan 1, 1990·Journal of Clinical Laboratory Analysis·M Biondi, G D Kotzalidis
Dec 1, 1991·Pflügers Archiv : European journal of physiology·T WatanabeN Murakami
Jan 1, 1989·European Archives of Psychiatry and Neurological Sciences·F Holsboer
Jan 1, 1991·Biotherapy·C Grunfeld, K R Feingold
Feb 1, 1989·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·H Baumann
Feb 1, 1995·Molecular Neurobiology·F ShintaniM Asai
Oct 12, 2007·Der Nervenarzt·N Müller, M J Schwarz
Jul 27, 2010·Neurotoxicity Research·Norbert MüllerMarkus J Schwarz
Nov 7, 1989·European Journal of Pharmacology·A UeharaM Namiki
Jan 1, 1989·Journal of Steroid Biochemistry·H O Besedovsky, A del Rey
Jan 1, 1990·Life Sciences·D L Palazzolo, S K Quadri
Jan 1, 1991·Life Sciences·T ShibasakiH Demura

❮ Previous
Next ❯

Related Concepts

Related Feeds


Aphasia affects the ability to process language, including formulation and comprehension of language and speech, as well as the ability to read or write. Here is the latest research on aphasia.