Corticotropin-releasing factor receptor type 2-deficient mice display impaired coping behaviors during stress

Genes, Brain, and Behavior
S C CosteM P Stenzel-Poore

Abstract

Two cognate receptors (CRF(1) and CRF(2)) mediate the actions of the stress-regulatory corticotropin-releasing factor (CRF) family of peptides. Defining the respective roles of these receptors in the central nervous system is critical in understanding stress neural circuitry and the development of psychiatric disorders. Here, we examined the role of CRF(2) in several paradigms that assess coping responses to stress. We report that CRF(2) knockout mice responded to a novel setting with increased aggressive behavior toward a bulbectomized conspecific male and show increased immobility during acute swim stress compared with wild-type mice. In addition, CRF(2)-deficient mice exhibited impaired adaptation to isolation stress as evinced by prolonged hypophagia and associated weight loss. Collectively, these results point toward a role for CRF(2) pathways in neural circuits that subserve stress-coping behaviors.

References

Aug 1, 1996·Physiology & Behavior·L L Liebenauer, B M Slotnick
Apr 29, 1998·European Journal of Pharmacology·C García-Lecumberri, E Ambrosio
Dec 17, 1998·The Journal of Endocrinology·L ArboreliusC B Nemeroff
Jan 20, 1999·Proceedings of the Association of American Physicians·P W Gold, G P Chrousos
Dec 2, 1999·Neuroscience and Biobehavioral Reviews·J M KoolhaasH J Blokhuis
Dec 22, 1999·Biological Psychiatry·T Steckler, F Holsboer
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Feb 13, 2001·The European Journal of Neuroscience·M E KeckR Landgraf
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·T M ReyesP E Sawchenko
May 5, 2001·Peptides·F M DautzenbergJ Moreau
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·K LewisW W Vale
Oct 30, 2001·Behavioural Brain Research·K A MiczekS Faccidomo
Jul 23, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Victoria B RisbroughMark A Geyer

❮ Previous
Next ❯

Citations

Oct 27, 1999·Regulatory Peptides·S C WeningerJ A Majzoub
Nov 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victoria B RisbroughFlorian Holsboer
Feb 22, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Francesco PapaleoAngelo Contarino
Feb 9, 2012·Journal of Molecular Endocrinology·Anna RiesterFelix Beuschlein
Apr 25, 2012·Neurobiology of Disease·Thibault RenoirAnthony J Hannan
Apr 9, 2014·Journal of Molecular Endocrinology·David A LovejoyJon del Castillo
Sep 9, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Kim VeroudeStephen V Faraone
Jun 24, 2015·The Journal of Comparative Neurology·Annaliese K BeeryMelissa M Holmes
Oct 8, 2008·Psychiatry Research·Isabel KrugFernando Fernández-Aranda
Aug 19, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Florian FreudenbergWilliam H J Norton
Jul 28, 2006·Hormones and Behavior·Victoria B Risbrough, Murray B Stein
Oct 28, 2011·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Julia HuemerHans Steiner
Nov 23, 2018·Cell and Tissue Research·Shlomo Wagner
Jul 21, 2007·Endocrinology·Nirupa Goel, Tracy L Bale
Jul 23, 2020·Trends in psychiatry and psychotherapy·Mailton VasconcelosRosa Maria M de Almeida

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.