Corticotropin-releasing hormone (CRH)-containing neurons in the immature rat hippocampal formation: light and electron microscopic features and colocalization with glutamate decarboxylase and parvalbumin

Hippocampus
X X YanT Z Baram

Abstract

Corticotropin-releasing hormone (CRH) excites hippocampal neurons and induces death of selected CA3 pyramidal cells in immature rats. These actions of CRH require activation of specific receptors that are abundant in CA3 during early postnatal development. Given the dramatic effects of CRH on hippocampal neurons and the absence of CRH-containing afferents to this region, we hypothesized that a significant population of CRHergic neurons exists in developing rat hippocampus. This study defined and characterized hippocampal CRH-containing cells by using immunocytochemistry, ultrastructural examination, and colocalization with gamma-aminobutyric acid (GABA)-synthesizing enzyme and calcium-binding proteins. Numerous, large CRH-immunoreactive (ir) neurons were demonstrated in CA3 strata pyramidale and oriens, fewer were observed in the corresponding layers of CA1, and smaller CRH-ir cells were found in stratum lacunosum-moleculare of Ammon's horn. In the dentate gyrus, CRH-ir somata resided in the granule cell layer and hilus. Ultrastructurally, CRH-ir neurons had aspiny dendrites and were postsynaptic to both asymmetric and symmetric synapses. CRH-ir axon terminals formed axosomatic and axodendritic symmetric synapses with pyramidal...Continue Reading

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Citations

Jul 19, 2006·Cell and Tissue Research·Chiara SalioAdalberto Merighi
Jun 19, 2013·Journal of Chemical Neuroanatomy·Krisztina J Kovács
Oct 23, 2013·Frontiers in Neuroendocrinology·Limor Regev, Tallie Z Baram
Sep 11, 2002·Trends in Neurosciences·Sarit Avishai-ElinerTallie Z Baram
Apr 12, 2002·Progress in Neurobiology·A Merighi
Jan 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Libor Velísek
Oct 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yuncai ChenTallie Z Baram
Oct 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Benno RoozendaalTallie Z Baram
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gerd PoeggelKatharina Braun
Jun 5, 2003·Molecular Neurobiology·Kristen L BrunsonTallie Z Baram
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Autumn S IvyTallie Z Baram
Feb 19, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benedict J KolberLouis J Muglia
Feb 24, 2009·Brain & Development·Céline M DubéTallie Z Baram
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Aug 2, 2006·Reviews in the Neurosciences·Luis Orozco-CabalJoel P Gallagher

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