CortiQ-based Real-Time Functional Mapping for Epilepsy Surgery

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
Christoph KapellerChristoph Guger

Abstract

To evaluate the use of the cortiQ-based mapping system (g.tec medication engineering GmbH, Austria) for real-time functional mapping (RTFM) and to compare it to results from electrical cortical stimulation mapping (ESM) and functional magnetic resonance imaging (fMRI). Electrocorticographic activity was recorded in 3 male patients with intractable epilepsy by using cortiQ mapping system and analyzed in real time. Activation related to motor, sensory, and receptive language tasks was determined by evaluating the power of the high gamma frequency band (60-170 Hz). The sensitivity and specificity of RTFM were tested against ESM and fMRI results. "Next-neighbor" approach demonstrated [sensitivity/specificity %] (1) RTFM against ESM: 100.00/79.70 for hand motor; 100.00/73.87 for hand sensory; -/87 for language (it was not identified by the ESM); (2) RTFM against fMRI: 100.00/84.4 for hand motor; 66.70/85.35 for hand sensory; and 87.85/77.70 for language. The results of the quantitative "next-neighbor" RTFM evaluation were concordant to those from ESM and fMRI. The RTFM correlates well with localization of hand motor function provided by ESM and fMRI, which may offer added localization in the operating room and guidance for extraoper...Continue Reading

References

Apr 9, 2005·Brain : a Journal of Neurology·Alon SinaiNathan E Crone
Aug 23, 2008·NeuroImage·Gerwin SchalkJonathan R Wolpaw
Dec 17, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A SinaiD Boatman-Reich
Mar 24, 2009·Journal of Magnetic Resonance Imaging : JMRI·Jennifer J VannestScott K Holland
May 19, 2010·Epilepsy & Behavior : E&B·Jarod RolandEric C Leuthardt
Apr 17, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Thomas Grunwald, Johannes Sarnthein
Apr 17, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuaki KojimaEishi Asano
Jun 12, 2012·Journal of Neurosurgery. Pediatrics·Carter D WrayJeffrey G Ojemann
Sep 25, 2012·Experimental Brain Research·Nicholas R AndersonDaniel W Moran
Nov 13, 2012·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuaki KojimaEishi Asano
Jan 24, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M J VansteenselN F Ramsey
May 22, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuaki KojimaEishi Asano
Aug 6, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Katsuaki KojimaEishi Asano

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Citations

Mar 3, 2018·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Anthony L RitaccioGerwin Schalk
Jul 26, 2019·Journal of Neural Engineering·Paolo G GabrielV Gilja
Nov 25, 2020·Neurosurgery·Jarod L RolandEric C Leuthardt
Aug 20, 2021·Frontiers in Neurology·Kohei KanayaSumio Kobayashi

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