Cortisol alters gene expression during involution of the rat ventral prostate

Molecular Endocrinology
P S RennieL Main

Abstract

The ability of high doses of cortisol to retard the involution process in the rat ventral prostate was related to alterations in the pattern of gene expression. Poly(A)+ RNA preparations from the prostates of noncastrated, castrated, and castrated rats injected daily for 7 days with cortisol were compared by Northern blot hybridizations for the relative expression of genes associated with cell differentiation and maintenance (the C1 prostatic steroid binding protein gene and alpha-tubulin), with cell death (TRPM-2, hsp 70, and c-fos), and with hormone regulation (the androgen and glucocorticoid receptors). As anticipated, the concentration of C1 mRNA in the prostate fell to less than 4% of that in the noncastrated controls within 4 days after castration and was nearly undetectable after 7 days. This decline was retarded by cortisol treatment of 7-day castrated animals which sustained the level of C1 transcripts at approximately 50% of control. While the pattern of expression of alpha-tubulin indicated some minor fluctuations, with the highest level occurring 7 days after castration, the prostates of the cortisol-treated group had essentially the same concentration of this mRNA as the noncastrates. Cortisol also modified the exp...Continue Reading

Citations

Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YamamotoY Komatsu
Sep 1, 1992·Cancer Metastasis Reviews·M P TenniswoodJ E Welsh
Aug 6, 2000·Cell and Tissue Research·R D Medh, E B Thompson
Oct 1, 1990·Molecular and Cellular Endocrinology·M Onoda, D Djakiew
Dec 29, 1995·Molecular and Cellular Endocrinology·K L BurnsteinD J Cameron
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·C L EatonK Griffiths
Jan 1, 1995·Critical Reviews in Oncology/hematology·M Koutsilieris
Mar 2, 1999·Microvascular Research·H ZoellnerB R Binder
Dec 8, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Keely M McNamaraUlla Simanainen
Jun 25, 2010·Molecular and Cellular Endocrinology·Erick J R SilvaMaria Christina W Avellar
Dec 4, 2012·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Eleonora RegueiraNora Raquel Ceballos
Aug 1, 1998·Biochimica Et Biophysica Acta·M AmbiliP R Sudhakaran
Mar 1, 1995·Microscopy Research and Technique·G SrinivasanN Bashirelahi
Dec 7, 2006·The Journal of Biological Chemistry·Dawn R CochraneColleen C Nelson
Jul 1, 2017·International Journal of Experimental Pathology·Julia Quilles AntoniassiSebastião Roberto Taboga
Oct 31, 1989·Biochemical and Biophysical Research Communications·F ClaessensW Rombauts

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.