Cortisol and depression: three questions for psychiatry

Psychological Medicine
J Herbert

Abstract

Cortisol plays a multifaceted role in major depression disorder (MDD). Diurnal rhythms are disturbed, there is increased resistance to the feedback action of glucocorticoids, excess cortisol may induce MDD, basal levels may be higher and the post-awakening cortisol surge accentuated in those at risk for MDD. Does this suggest new avenues for studying MDD or its clinical management? The relevant literature was reviewed. Cortisol contributes to genetic variants for the risk for MDD and the way that environmental events amplify risk. The corticoids' influence begins prenatally, but continues into adulthood. The impact of cortisol at each phase depends not only on its interaction with other factors, such as psychological traits and genetic variants, but also on events that have, or have not, occurred previously. This review suggests that the time is now right for serious consideration of the role of cortisol in a clinical context. Estimates of cortisol levels and the shape of the diurnal rhythm might well guide the understanding of subtypes of MDD and yield additional indicators for optimal treatment. Patients with disturbed cortisol rhythms might benefit from restitution of those rhythms; they may be distinct from those with more ...Continue Reading

References

Jan 11, 1990·Life Sciences·R M WalterC L Keen
Mar 1, 1989·The American Journal of Psychiatry·R G KatholW H Meller
Feb 1, 1986·The British Journal of Oral & Maxillofacial Surgery·B O Abiose
Sep 1, 1985·Archives of General Psychiatry·B PfohlR Stone
Jan 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·G W BrownT O Harris
Sep 1, 1985·Psychiatry Research·D von ZerssenK M Pirke
Jul 6, 1968·Lancet·P W Butler, G M Besser
Jan 1, 1973·Archives of General Psychiatry·E J SacharT F Gallagher
Dec 1, 1966·The British Journal of Psychiatry : the Journal of Mental Science·P K Bridges, M T Jones
Sep 1, 1982·Journal of Affective Disorders·P M GrahamL S Cox
Sep 1, 1984·The Journal of Clinical Endocrinology and Metabolism·N OrentreichJ H Vogelman
Nov 1, 1983·Journal of Affective Disorders·D A Lewis, R E Smith
Jan 1, 1982·Psychoneuroendocrinology·G M AsnisE J Sachar
Dec 1, 1982·Archives of General Psychiatry·G B Parker, L B Brown
Jul 1, 1980·Archives of General Psychiatry·W A Brown, I Shuey
Jan 1, 1981·Journal of Psychosomatic Research·E Teiramaa
Jul 1, 1980·Archives of General Psychiatry·M A SchlesserB M Sherman
Dec 1, 1994·Hormones and Behavior·H UnoJ Holden
Nov 30, 1994·Annals of the New York Academy of Sciences·F HolsboerK Wiedemann
Aug 1, 1993·Cellular and Molecular Neurobiology·P RosenfeldE R de Kloet
Oct 1, 1996·The Journal of Clinical Psychiatry·A J RushN Vasavada
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M DeuschleI Heuser
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·O KhorramS S Yen
Jan 1, 1997·Acta Psychiatrica Scandinavica·T G DinanC Berti
May 15, 1997·Journal of Neuroscience Research·M J SchaafE Vreugdenhil
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·V G KimonidesJ Herbert
Nov 11, 1998·Nature Medicine·P S ErikssonF H Gage
Dec 17, 1998·The Journal of Endocrinology·L ArboreliusC B Nemeroff
Feb 6, 1999·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F HucklebridgeP Evans
Jun 8, 1999·Archives of General Psychiatry·J W NewcomerA L Alderson
Jul 1, 1999·Biological Psychiatry·O M WolkowitzJ Canick
Nov 24, 1999·Biological Psychiatry·R S DumanJ Thome

❮ Previous
Next ❯

Citations

Feb 6, 2014·Psychoneuroendocrinology·Marianne Agergaard VammenJane Frølund Thomsen
Jan 24, 2013·Translational Psychiatry·R Kaddurah-DaoukO Fiehn
Jun 12, 2013·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Camelia E Hostinar, Megan R Gunnar
May 16, 2013·Reproductive Biology and Endocrinology : RB&E·Juan J TarínAntonio Cano
Jun 5, 2014·Psychiatry Research·Deidre M AnglinMonique J Brown
Apr 11, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andres M KannerMatthias Koepp
Feb 26, 2016·Neuroscience and Biobehavioral Reviews·Anand GururajanJohn F Cryan
Dec 1, 2014·Journal of Psychosomatic Research·Bart G OosterholtMichiel A J Kompier
May 25, 2013·Endocrinology and Metabolism Clinics of North America·Johannes D VeldhuisFerdinand Roelfsema
Mar 5, 2016·Archives of Women's Mental Health·Elizabeth C BraithwaitePaul G Ramchandani
Nov 17, 2015·Early Childhood Research Quarterly·Daniel S LumianSarah Enos Watamura
Sep 22, 2015·Psychological Medicine·C SmartR H McAllister-Williams
Feb 18, 2014·British Journal of Pharmacology·C V Perani, D A Slattery
Jul 22, 2014·Journal of Neuroendocrinology·D ToufexisV Viau
Feb 25, 2015·Depression and Anxiety·Nicola S Schutte, John M Malouff
Jul 8, 2015·Psychoneuroendocrinology·Elizabeth C BraithwaiteSusannah E Murphy
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matthew OwensIan M Goodyer
May 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gertrud L HaverkampCarl E Siegert
Jul 5, 2016·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Liz RietschelNicholas G Martin
Sep 24, 2016·Journal of Psychiatric Research·Matias Carvalho Aguiar MeloVeralice Meireles Sales de Bruin
Aug 16, 2016·Occupational Medicine·H JanssensL Braeckman
Feb 22, 2017·British Journal of Pharmacology·Kanza M KhanDavid J Echevarria
Feb 11, 2014·Therapeutic Advances in Cardiovascular Disease·Lauren WrightMeir Steiner
Nov 4, 2017·International Journal of Molecular Sciences·Tadahiro NumakawaNaoki Adachi
Apr 24, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Amel MessaoudStefano Comai
Jul 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian OtteKim Hinkelmann
Sep 4, 2018·Obesity·Kristine M MolinaMilagros C Rosal
May 3, 2018·Military Medicine·Adam R CobbMichael J Telch

❮ Previous
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