Cortisol and immune measures in boars exposed to three-day administration of exogenous adrenocorticotropic hormone

Veterinary Research Communications
N BilandzićI Barac

Abstract

The aim of the study was to evaluate the effect of adrenal stimulation by adrenocorticotropic hormone (ACTH) on blood cortisol concentration and on circulating total and differential leukocyte counts during and in the 16 days after ACTH administration. Swedish Landrace boars aged approximately 6-7 months were used. ACTH-treated animals (n = 7) were given ACTH intravenously at 10 microg/kg body mass for 3 days. A control group of animals (n = 7) received 1 ml of sterile 0.9% saline intramuscularly. ACTH induced a highly significant increase (p>0.0001) in serum cortisol in treated boars. On the day after the last ACTH dose, the cortisol concentration was significantly higher, but the level of significance was lower than during ACTH administration (p>0.05). During ACTH treatment, a significant increase was recorded in total leukocyte count and neutrophil percentage (p>0.05 to p>0.0001), along with the increase in blood cortisol concentration, whereas percentage lymphocyte count showed a significant decrease. Lymphopenia disappeared upon cessation of treatment, but neutropenia developed in the week after treatment. On all three days of ACTH challenge, the neutrophil-to-lymphocyte ratio was significantly increased. An increase in eo...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·J P NorthropP S Mattila
Aug 1, 1991·Journal of Animal Science·J E Minton, F Blecha
Nov 1, 1990·Immunology Today·J Westermann, R Pabst
May 1, 1990·Immunology Today·D N KhansariR E Faith
Jan 1, 1989·Proceedings of the Society for Experimental Biology and Medicine·H G KlemckeG L Hahn
Feb 1, 1989·Veterinary Immunology and Immunopathology·J F Griffin
Jul 1, 1983·Journal of Animal Science·R Dantzer, P Mormède
Sep 1, 1994·Veterinary Immunology and Immunopathology·P WallgrenC Fossum
Nov 1, 1994·Veterinary Immunology and Immunopathology·M J HessingP R Wiepkema
Oct 1, 1994·Journal of Animal Science·J L Morrow-TeschJ L Salak-Johnson
Sep 1, 1994·Journal of Animal Science·C L Stull, S P McDonough
Mar 14, 1998·Journal of Animal Science·T A HicksR L Norman
Jan 21, 2000·Journal of Animal Science·J D BishopG D Weesner
Jun 29, 2000·QJM : Monthly Journal of the Association of Physicians·T M O'ConnorF Shanahan
Jul 11, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A M MwanzaS Einarsson
Jun 12, 2001·Physiology & Behavior·J de GrootW J Boersma

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Citations

Sep 24, 2013·Journal of Dairy Science·C S WilcoxS D Eicher
Jun 19, 2015·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Mandy J Keogh, Shannon Atkinson
Dec 14, 2017·Photodermatology, Photoimmunology & Photomedicine·Keiichi HiramotoSatoshi Yokoyama
Jan 16, 2020·Animals : an Open Access Journal From MDPI·Martin W SeltmannVirpi Lummaa
Oct 4, 2018·International Journal of Molecular Sciences·Elisa WirthgenEllen Kanitz

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