PMID: 2498943Jan 1, 1989Paper

Cortisol and treatment of depression: predictive value of spontaneous and suppressed cortisol levels and course of spontaneous plasma cortisol

Psychopharmacology
P ChristensenS Nielsen

Abstract

In 72 consecutive depressed hospitalized patients afternoon plasma cortisol was measured in three ways before treatment with antidepressants: 1) Spontaneous (n = 72), 2) 2h after oxazepam suppression (45 mg, n = 28; 60 mg, n = 37) and 3) 16 h after dexamethasone suppression (2 mg, n = 71). In addition, spontaneous cortisol was measured after 3 weeks' treatment (n = 55) and 5 weeks' treatment (n = 36). Both spontaneous and suppressed cortisol levels seemed to have a predictive value in the endogenously depressed patients: complete responders had significantly lower pretreatment cortisol levels compared to poor responders. However, other covarying factors such as distress and age may as well account for the differences in treatment effect. During treatment a significant decrease of spontaneous cortisol was found from about 400 nM in poor responders and 325 nM in complete responders to about 300 nM in all groups. There was a positive correlation between pre- and post-treatment cortisol levels and between pretreatment levels and per cent fall in spontaneous cortisol levels.

References

Nov 1, 1976·The Journal of Nervous and Mental Disease·J J Bartko, W T Carpenter
Mar 1, 1975·Acta Psychiatrica Scandinavica·P BechT G Bolwig
May 1, 1985·Journal of Affective Disorders·P ChristensenH Y Thomsen
May 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·E D Myers
Dec 1, 1988·Acta Psychiatrica Scandinavica·P ChristensenL F Gram
Mar 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenK Wood
Jan 1, 1973·Acta Psychiatrica Scandinavica·P Kragh-SorensenM Asberg
Aug 1, 1972·The British Journal of Psychiatry : the Journal of Mental Science·C GurneyK Schapira
Dec 1, 1967·The British Journal of Social and Clinical Psychology·M Hamilton
Jan 1, 1983·Psychopharmacology·J D AmsterdamK Rickels
Mar 1, 1982·The British Journal of Psychiatry : the Journal of Mental Science·B J Carroll
Sep 1, 1982·Archives of General Psychiatry·W H NelsonS R Shane
Aug 1, 1980·Acta Psychiatrica Scandinavica·P BechO J Rafaelsen
Jul 1, 1965·Archives of General Psychiatry·J W MASONJ H HANDLON
Aug 1, 1965·The British Journal of Psychiatry : the Journal of Mental Science·M W CARNEYR F GARSIDE

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