DOI: 10.1101/514968Jan 9, 2019Paper

Cortisol associated with hypometabolism across the Alzheimer's disease spectrum

BioRxiv : the Preprint Server for Biology
Miranka WirthCatharina Lange


Objective: Hypothalamic-pituitary-adrenal (HPA) dysregulation is proposed as a risk factor for Alzheimer's disease (AD). This cross-sectional study assessed relationships between plasma cortisol levels and neuroimaging biomarkers, specifically brain glucose metabolism and gray matter volume, across the AD spectrum. Methods: Cognitively normal older adults and patients with mild cognitive impairment (MCI) and AD dementia were included from the Alzheimer's Disease Neuroimaging Initiative. Participants (n = 556) were selected based on availability of baseline measures of plasma cortisol levels and gray matter volume, as estimated with magnetic resonance imaging. Within a subsample (n = 288), we examined brain glucose metabolism (n = 288) as with positron emission tomography. Relationships between plasma cortisol and AD neuroimaging biomarkers were assessed using regions-of-interest and voxel-wise analyses. Results: Across the entire cohort, higher plasma cortisol was also related to lower gray matter volume, most notably in the left lateral temporal-parietal-occipital regions. Importantly, higher plasma cortisol concentration was also related to hypometabolism, especially in lateral temporo-parietal and medial parietal regions. Wh...Continue Reading

Related Concepts

Alzheimer's Disease
Biological Markers
Cross-Sectional Studies
General Adaptation Syndrome
Gray Matter
Hypothalamic Structure
Magnetic Resonance Imaging
Pathologic Processes

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