Jun 29, 2013

Cortisol at the emergency room rape visit as a predictor of PTSD and depression symptoms over time

Psychoneuroendocrinology
Kate WalshHeidi S Resnick

Abstract

Dysregulation of the hypothalamic-pituitary-adrenal axis, typically reflected by alterations in cortisol responsivity, has been associated with exposure to traumatic events and the development of stress-related disorders such as posttraumatic stress disorder (PTSD) and depression. Serum cortisol was measured at the time of a post sexual assault medical exam among a sample of 323 female victims of recent sexual assault. Analyses were conducted among 235 participants who provided data regarding history of previous assault as well as PTSD and depression symptoms during at least one of the three follow-ups. Growth curve models suggested that prior history of assault and serum cortisol were positively associated with the intercept and negatively associated with the slope of PTSD and depression symptoms after controlling for covariates. Prior history of assault and serum cortisol also interacted to predict the intercept and slope of PTSD and depression symptoms such that women with a prior history of assault and lower ER cortisol had higher initial symptoms that decreased at a slower rate relative to women without a prior history and those with higher ER cortisol. Prior history of assault was associated with diminished acute cortisol...Continue Reading

  • References37
  • Citations25

References

Mentioned in this Paper

Biological Adaptation to Stress
Adrenal Gland Hyperfunction
Contraceptives, Oral
Post-Traumatic Stress Disorder
Serum Cortisol Measurement
Delayed Onset Post-Traumatic Stress Disorder
Serum cortisol
Depressive Symptoms
Nicotine
Forcible Intercourse

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