PMID: 6105025Jun 1, 1980Paper

Cortisol, growth hormone and prolactin responses to insulin-induced hypoglycaemia in hyperthyroid patients before and during beta-adrenoceptor blockade

Clinical Endocrinology
O R NilssonB Kågedal

Abstract

Two beta-adrenoceptor blocking agents, metoprolol (beta-1-selective) and propranolol (non-selective), were used in the treatment of hyperthyroid patients. The response of pituitary stress hormones to insulin-induced hypoglycaemia was investigated before and during beta-adrenoceptor blockage. Treatment with metoprolol (n=10) or propranolol (n=10) produced no changes in the cortisol or prolactin responses to hypoglycaemia. Moreover the growth hormone response remained unaltered during treatment with metoprolol. A small, but statistically significant, augmentation of growth hormone response was obtained during treatment with propranolol. When twelve subjects, euthyroid after final conventional treatment (surger), radioiodine or thyrostatic drugs), were re-examined, the cortisol and prolactin responses were unchanged, although growth hormone concentrations reached a slightly higher maximum value (P less than 0.01). It was concluded that treatment with beta-blocking agents in hyperthyroid subjects has no clinically important influence on the release of pituitary stress hormones during hypoglycaemia.

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Citations

Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Oct 1, 1990·British Journal of Clinical Pharmacology·R J WaldenB N Prichard
Apr 1, 1992·Journal of Endocrinological Investigation·R ValcaviI Portioli

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