Cortisol levels in plasma and aqueous humour of patients with steroid induced and other glaucomas

Vestnik oftalmologii
E M Kasimov, F A Aghaeva

Abstract

The paper describes the role of endogenous glucocorticoids in the pathogenesis of open-angle glaucoma. As to steroid-induced glaucoma (SG), however, indicators of systemic and local cortisol metabolism are yet underinvestigated. Aim - to determine and compare systemic (plasma) and local (aqueous humour) cortisol concentrations in patients with SG and other types of glaucoma (OTG). A prospective analysis was conducted in 64 patients who underwent plasma and aqueous humor sampling. All the patients were divided into 4 groups: group 1 - 11 patients with steroid induced ocular hypertension (SOH) and SG; group 2 - 31 patients with OTG; group 3 - 10 patients on steroid therapy (ST) without a so called 'steroid response'; group 4 - the controls (12 patients with cataract). The mean cortisol levels in plasma and aqueous humour were the following: 177.5±29.4 ng/ml and 53.1±12.2 ng/ml in patients with SOH and SG; 277.7±33.6 ng/ml and 44.6±4.4 ng/ml in patients with OTG; 125.2±28.1 ng/ml in patients on ST; 147.2±19.1 ng/ml and 29.8±3.2 ng/ml in the controls. The highest plasma and aqueous humour cortisol levels were found in groups 2 and 1, respectively. Plasma and aqueous humour levels of cortisol appeared to be higher in glaucoma patien...Continue Reading

References

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Apr 25, 2013·Endocrine Reviews·Laura L GathercolePaul M Stewart
Dec 4, 2013·Journal of Medicinal Chemistry·James S ScottAndrew V Turnbull

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Citations

Apr 15, 2020·Journal of Glaucoma·Samantha Sze-Yee LeeDavid A Mackey
Nov 13, 2019·Journal of Glaucoma·Tanuj DadaJyoti Shakrawal

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