Cortisol pretreatment enhances the lung growth response to tracheal obstruction in fetal sheep

The American Journal of Physiology
Rochelle E BolandS B Hooper

Abstract

We have investigated whether cortisol pretreatment of sheep fetuses will result in a greater liquid accumulation within the lung and a greater lung growth response to obstruction of the fetal trachea. Chronically catheterized fetal sheep received either 1) a cortisol infusion at an increasing dose (1.5-4.0 mg/day) from days 118 to 127 of gestation; the fetal trachea was then obstructed from days 128 to 131 of gestation (n = 4); 2) a saline infusion from days 118 to 127 of gestation; the fetal trachea was then obstructed from days 128 to 131 of gestation (n = 4); or 3) a saline infusion from days 118 to 127 of gestation with no period of tracheal obstruction (control; n = 4). Fetal tracheal pressures were measured from days 128 to 131 of gestation, whereas lung liquid secretion rates and volumes were measured on days 118, 128, and 131 of gestation. On day 131 of gestation, all fetuses were given an intravenous injection of [3H]thymidine and were killed 8 h later. Cortisol pretreatment increased the volume of liquid that accumulated within the fetal lung from 69.5 +/- 4.1 to 96.1 +/- 14.1 ml/kg after 3 days of tracheal obstruction. Similarly, cortisol pretreatment significantly enhanced the increase in lung DNA content from 257.4...Continue Reading

References

Aug 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·W MitznerA E Palmer
Oct 1, 1990·The Journal of Clinical Investigation·A C MoessingerG T Kiu
Oct 1, 1995·American Journal of Respiratory and Critical Care Medicine·M IkegamiR Kelly
Apr 1, 1995·Clinical and Experimental Pharmacology & Physiology·S B Hooper, R Harding
Dec 1, 1993·Journal of Applied Physiology·A A MillerR Harding
May 1, 1996·Experimental Lung Research·E KeramidarisR Harding
Jul 1, 1996·Journal of Applied Physiology·R Harding, S B Hooper

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Citations

Apr 8, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jyoji YoshizawaJoseph A Kitterman
Aug 10, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharon J FlecknoeStuart B Hooper
Aug 19, 2007·The Journal of Physiology·Foula SozoMegan J Wallace
Mar 3, 2009·Experimental Physiology·Abigail L Fowden, Alison J Forhead

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