PMID: 2104527Dec 1, 1990Paper

Cortisol production rate in childhood and adolescence

The Journal of Pediatrics
B L LinderF Cassorla

Abstract

We studied the daily cortisol production rate in 33 normal children and adolescents, using a stable isotope-dilution technique employing high-performance liquid chromatography-mass spectrometry. Two indwelling intravenous catheters were inserted and tracer 9,12,12-2H3-cortisol (deuterated cortisol) was infused continuously for 30 hours. After 6 hours of tracer infusion to allow for equilibration, blood was obtained every 20 minutes for 24 hours. The mean (+/- SD) cortisol production rate was 9.5 +/- 2.5 mg/day (6.8 +/- 1.9 mg/m2/day). Cortisol production rate did not vary with sex or pubertal stage. These results suggest that the cortisol production rate in children and adolescents is significantly lower than previously estimated.

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Citations

Apr 28, 2006·Pediatric Endocrinology Reviews : PER·Catherine Dacou-Voutetakis, Maria Dracopoulou
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