Cortisol Regeneration in the Fetal Membranes, A Coincidental or Requisite Event in Human Parturition?

Frontiers in Physiology
Wang-Sheng WangKang Sun

Abstract

The fetal membranes are equipped with high capacity of cortisol regeneration through the reductase activity of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1). The expression of 11β-HSD1 in the fetal membranes is under the feedforward induction by cortisol, which is potentiated by proinflammatory cytokines. As a result, the abundance of 11β-HSD1 increases with gestational age and furthermore at parturition with an escalation of cortisol concentration in the fetal membranes. Accumulated cortisol takes parts in a number of crucial events pertinent to the onset of labor in the fetal membranes, including extracellular matrix (ECM) remodeling and stimulation of prostaglandin output. Cortisol remodels the ECM through multiple approaches including induction of collagen I, III, and IV degradation, as well as inhibition of their cross-linking. These effects of cortisol are executed through activation of the autophagy, proteasome, and matrix metalloprotease 7 pathways, as well as inhibition of the expression of cross-linking enzyme lysyl oxidase in mesenchymal cells of the membranes. With regard to prostaglandin output, cortisol not only increases prostaglandin E2 and F2α syntheses through induction of their synthesizing enzymes such as cy...Continue Reading

References

Jan 1, 1978·Prostaglandins·M J DuchesneA C de Paulet
Jun 1, 1979·Journal of Animal Science·N L First, M J Bosc
Feb 1, 1978·Prostaglandins·M D MitchellA C Turnbull
Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·A K TanswellB T Smith
Sep 1, 1991·American Journal of Respiratory Cell and Molecular Biology·H M Kagan, P C Trackman
Dec 1, 1988·The Journal of Clinical Endocrinology and Metabolism·F A PotestioD M Olson
Jul 1, 1986·Collagen and Related Research·S Shull, K R Cutroneo
Nov 1, 1981·Collagen and Related Research·K R CutroneoD F Counts
Jul 1, 1995·The Journal of Clinical Endocrinology and Metabolism·Z KrozowskiR K Andrews
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·W SchmidG Schütz
Nov 1, 1994·Molecular and Cellular Endocrinology·A L AlbistonZ S Krozowski
Jan 1, 1994·Experimental and Clinical Endocrinology·R Leiser, P Kaufmann
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·M L Casey, P C MacDonald
Jan 1, 1997·The Journal of Clinical Endocrinology and Metabolism·K SunJ R Challis
Jun 1, 1997·Endocrine Reviews·S Mesiano, R B Jaffe
May 1, 1997·Biochemical Society Transactions·K E ChapmanJ R Seckl
Nov 5, 1997·Annals of the New York Academy of Sciences·J R ChallisW Gibb
Mar 5, 1998·The New England Journal of Medicine·S Parry, J F Strauss
May 27, 1999·Journal of Perinatal Medicine·J R ChallisF Pomini
Jun 30, 2000·Human Reproduction Update·M Beato, J Klug
Jul 14, 2001·Frontiers of Hormone Research·S Mesiano

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Citations

Apr 21, 2021·Psychoneuroendocrinology·David Q StoyeRebecca M Reynolds
Dec 22, 2021·Stress : the International Journal on the Biology of Stress·Cihat UçarSedat Yıldız

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