PMID: 9658363Jul 11, 1998Paper

Cortisol upregulates HIV p24 antigen production in cultured human monocyte-derived macrophages

The Journal of the Association of Nurses in AIDS Care : JANAC
B SwansonG T Spear

Abstract

HIV infection is associated with hypercortisolemia. Since glucocorticoids have been shown to stimulate the replication of several viruses, we examined the effects of cortisol on HIV replication in cultured monocyte-derived macrophages (MDM), a cell type that has been proposed to serve as a viral reservoir. Our data revealed that physiological concentrations of cortisol upregulate viral replication in MDM. Because the dose-response curve for cortisol on HIV replication in vivo is not known, the clinical relevance of these findings remain uncertain. Clinical studies are needed to characterize the effects of corticosteroid therapy on viral burden in vivo.

References

Jan 1, 1992·Journal of Acquired Immune Deficiency Syndromes : JAIDS·N ChristeffE A Nunez
Dec 1, 1990·The Journal of Allergy and Clinical Immunology·A M Snowman, S H Snyder
May 1, 1991·The American Review of Respiratory Disease·S J Lane, T H Lee
Jan 15, 1986·International Journal of Cancer. Journal International Du Cancer·P D MarkhamR C Gallo
Jun 1, 1996·Nature Medicine·M S SaagP A Volberding
Jul 1, 1996·Nursing Research·N L McCainR M Novak

❮ Previous
Next ❯

Citations

Jul 7, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Seetharamaiah ChittiprolMahendra Kumar
Mar 7, 2008·Brain, Behavior, and Immunity·Jeffrey M GreesonNancy G Klimas
Aug 16, 2006·Journal of Health Psychology·Cheryl Gore-FeltonApril Winningham
May 6, 2009·Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie·Waldemar von Suchodoletz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.