Cortisone-induced cleft palate in A/J mice: failure of palatal shelf contact

Teratology
V M Diewert, R M Pratt

Abstract

Although cortisone treatment for induction of cleft palate in mice has been shown to delay the time of palatal shelf elevation, the effects of delayed elevation of shelf contact have not been critically evaluated in a cortisone-sensitive mouse strain. The objective of this study was to evaluated palatal development in cortisone-treated A/J mice in order to determine whether the shelves make contact upon elevation. Morphometric analysis of frozen sections revealed that cortisone-treated shelves were smaller than control shelves with apparent reductions in both the content of extracellular matrix and the number of cells. At a light microscopic level, thinning of medial epithelium in cortisone-treated palates appeared similar to that in untreated palates with spontaneous cleft lip and palate. Shelf elevation was delayed by approximately 12 hours and only half of the cortisone-treated palates achieved complete horizontal positioning of the shelves in all regions of the palate. Immediately after elevation, all control palates had extensive vertical contact along the complete length of the palate. In contrast, approximately 20% of the cortisone-treated fetuses had contact between the shelves in the middle palate region only, with the...Continue Reading

References

Feb 1, 1975·Teratology·R M Greene, D M Kochhar
Jan 1, 1979·Differentiation; Research in Biological Diversity·D S Salomon, R M Pratt
Jan 1, 1979·American Journal of Medical Genetics·M Vekemans, F C Fraser
Feb 1, 1978·Teratology·B E Walker, A Patterson
Dec 1, 1978·Journal of Cellular Physiology·D S Salomon, R M Pratt
Nov 1, 1967·The American Journal of Anatomy·L M Ross, B E Walker
Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·R M PrattK S Brown

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Citations

Apr 5, 2005·Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses·Linda Merritt
Feb 9, 1999·Plastic and Reconstructive Surgery·J WeinzweigL E Edstrom
Sep 8, 2001·Plastic and Reconstructive Surgery·S H KooJ H Grant
Sep 1, 1985·Environmental Health Perspectives·R M Pratt
Apr 5, 2000·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·M H Rajabian, M Sherkat
Oct 30, 2001·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·S G Gong, R L Eulenberg
Mar 23, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Sarvraj Singh Kohli, Virinder Singh Kohli
Mar 9, 2002·Journal of Endocrinological Investigation·N Ozbey
Apr 1, 1992·Teratology·B D Abbott, A R Buckalew
Jul 1, 1990·Teratology·J G BanniganA Morris
Jul 6, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Barbara D Abbott
Jan 9, 2014·Orthodontics & Craniofacial Research·N V HermannS Kreiborg
Oct 1, 1983·Experimental Cell Research·R I Grove, R M Pratt
Dec 1, 1982·Teratology·T Yoneda, R M Pratt
Aug 1, 1984·Teratology·R M PrattE H Goulding
Feb 1, 1989·Teratology·F S LondonK P Chepenik
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·R M PrattV M Diewert
May 11, 2004·The Journal of Veterinary Medical Science·Satoshi FurukawaIzumi Ogawa
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
Jan 1, 1995·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·M C Johnston, P T Bronsky
Mar 7, 2003·The Journal of Craniofacial Surgery·Francesco CarinciMauro Tognon
Jan 1, 1982·Teratogenesis, Carcinogenesis, and Mutagenesis·R M PrattW D Willis
Jun 17, 2000·Radiation Research·H HiranumaH Fuchihata
Nov 1, 1995·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·C A TrotmanD S Carlson
Oct 1, 1991·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·S C Freni, W F Zapisek
Mar 3, 1998·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·G D SinghS Lozanoff
Jun 1, 1995·Roux's Archives of Developmental Biology : the Official Organ of the EDBO·Teresa Ruth StreckerPhilantha Sue-Hwa Kon
Oct 31, 2020·Birth Defects Research·Michael A GarlandChengji J Zhou

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