Cortistatin protects myocardium from endoplasmic reticulum stress induced apoptosis during sepsis

Molecular and Cellular Endocrinology
Bo ZhangYongfen Qi

Abstract

Sepsis and septic shock are common entities encountered in intensive care units. Myocardial depression is a well-recognized manifestation of organ dysfunction in sepsis, and myocardial apoptosis is a key step for this progression, which may contribute to cardiac contractile dysfunction. Increasing evidence suggested the anti-inflammatory role of cortistatin (CST) during lethal endotoxemia. However, the direct protective effect of CST on myocardial is still not clear. Here, we aimed to study whether CST can directly protect myocardial from apoptosis. To test that, we used cecal ligation and puncture (CLP) induced sepsis rat model. CST (175 µg/kg, intraperitoneal administration) was injected every 24 h before the model induction for 3 days. Electron microscopy, TUNEL staining, caspase-3 expression, and the Bcl-2/Bax ratio were used to measure myocardial apoptosis. In addition, the protein levels of endoplasmic reticulum stress (ERS) markers were overexpressed in sepsis. To further test whether CST can directly protect myocardial apoptosis from ERS, we compared dithiothreitol (DTT) induced cardiomyocyte (CM) ERS with or without CST in vitro. We found that CST strongly attenuated lipopolysaccharide (LPS) and DTT induced CM ERS. Blo...Continue Reading

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Citations

Feb 6, 2016·Future Microbiology·Orhan Rasid, Jean-Marc Cavaillon
Oct 12, 2016·Molecular Therapy. Nucleic Acids·Hui WangJunjie Xiao
Oct 30, 2016·Peptides·Bo ZhangXiu-Ping Bai
Jun 20, 2020·Archives of Physiology and Biochemistry·Min LiMenghe Wang
Jul 18, 2018·Mediators of Inflammation·Xiaozhen ChenQingquan Lian
Apr 23, 2019·Experimental and Therapeutic Medicine·Jianping LiuQinghong Cheng
Aug 29, 2017·Oxidative Medicine and Cellular Longevity·Shiyan PengFeng Xiao
Dec 20, 2019·IUBMB Life·Youyou YanChunli Song
May 11, 2021·Frontiers in Pharmacology·Zixuan LiuXianli Meng
Jul 20, 2021·Journal of Cellular Physiology·Runze WangMingming Zhang
Oct 4, 2021·Bioscience, Biotechnology, and Biochemistry·Meixue ChenChunfeng Liu

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