Abstract
The aim of the present investigation was to evaluate the effect of an extract from Corydalis yanhusuo W.T., a Chinese herbal medicine, on ischemia/reperfusion (I/R) injury and to determine the mechanism(s) involved. In rats, the left anterior descending (LAD) coronary artery was occluded for 30 min and then reperfused for 6 h. 0.5% carboxymethyl cellulose sodium was used as a vehicle (I/R control group) and Corydalis yanhusuo rhizoma extract (I/R + CY 200, 100 mg/kg groups) were given. Infarct size and hemodynamic parameters were measured. Apoptosis was detected quantitatively by the terminal transferase dUTP nick end-labeling (TUNEL) method and confirmed by DNA laddering on agarose gel. The expression of anti-apoptotic Bcl-2 and pro-apoptotic Bax proteins was visualized by western blot analysis. In contrast to the I/R control group, administration with CY 200 mg/kg resulted in a significant reduction in the infarct size and an improvement in heart function as evidenced by higher LVSP and +/-dp/dtmax. TUNEL-positive cells in the ischemic myocardium were also significantly reduced in the I/R + CY 200, 100 mg/kg groups, consistent with little DNA laddering in these two groups. Furthermore, greater Bcl-2 and attenuated Bax express...Continue Reading
References
Feb 1, 1992·Cardiovascular Research·D J Hearse, R Bolli
Feb 1, 1994·Biological & Pharmaceutical Bulletin·M KuboH Shiomoto
Oct 1, 1994·The Journal of Clinical Investigation·R A GottliebR L Engler
Oct 1, 1995·Pharmacology·F Y ChuehM T Lin
Aug 1, 1996·Experimental Cell Research·W ChengP Anversa
Oct 1, 1996·Circulation·J MisaoH Fujiwara
Apr 1, 1997·Biological & Pharmaceutical Bulletin·H MatsudaM Kubo
Oct 7, 1997·Circulation·L A Kirshenbaum, D de Moissac
Oct 7, 1998·Circulation·L M Buja, M L Entman
Mar 4, 2000·Circulation Research·A Haunstetter, S Izumo
Mar 18, 2000·Heart·D M Yellon, G F Baxter
Mar 21, 2000·Journal of Molecular and Cellular Cardiology·B FreudeJ Schaper
Jan 3, 2001·Journal of Molecular and Cellular Cardiology·Z Q ZhaoJ Vinten-Johansen
Jul 11, 2001·Apoptosis : an International Journal on Programmed Cell Death·Z Q ZhaoJ Vinten-Johansen
Dec 18, 2001·Planta medica·Y L LeeH S Tsay
Citations
Jun 11, 2010·Chinese Journal of Integrative Medicine·Fu-yong ChuZhi-zhong Li
Dec 4, 2008·The American Journal of Chinese Medicine·Lindsey N JacksonB Mark Evers
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Tae Ho LeeSun Yeou Kim
Dec 4, 2012·International Journal of Molecular Sciences·Bohui LiLing Yang
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qing LiuDaping Fan
Oct 15, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiu-Yue LiYue Shi
Oct 16, 2015·International Journal of Molecular Medicine·Jianfang CaoChen Wang
Nov 14, 2012·Journal of Pharmaceutical and Biomedical Analysis·Shuping WangRunhui Liu
Aug 30, 2007·The Journal of Pharmacy and Pharmacology·Chengping WenLianda Li
May 26, 2007·The Journal of Pharmacy and Pharmacology·Limao WuMinle He
Sep 25, 2012·Chirality·Si-Yuan SunHui-Di Jiang
Jul 16, 2013·Journal of Ethnopharmacology·Peng LiLing Yang
Oct 8, 2013·Journal of Ethnopharmacology·Xin-Yuan ZhuMei-Lin Liu
Aug 20, 2014·BMC Complementary and Alternative Medicine·Jingjing YanChunhuan Jin
Aug 26, 2016·Pharmaceutical Biology·Qian ZhangFeng-Qing Yang
Jun 26, 2017·Journal of Ethnopharmacology·Qiuyue LiYue Shi
Oct 3, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhong-Ze MaDavid Y W Lee
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huanyu GuanYue Shi
Aug 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Binbin CuiChunjuan Yang
Jan 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiying DouLiu Cao
Feb 1, 2020·Recent Patents on Anti-cancer Drug Discovery·Hongyu TaoXiukun Lin
Mar 21, 2020·Scientific Reports·Yin LuDeyong Zhang
Apr 1, 2016·Journal of Food and Drug Analysis·Hsin-Yi Hung, Tian-Shung Wu
Dec 12, 2019·BMC Complementary and Alternative Medicine·Li WanXiaoping Qian
Apr 1, 2020·Pharmaceutical Biology·Bing TianShu-Ming Huang
May 30, 2009·Journal of Separation Science·Jing ZhangXinmiao Liang
Dec 8, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Wenchao DanQingyong He