Corydalis yanhusuo rhizoma extract reduces infarct size and improves heart function during myocardial ischemia/reperfusion by inhibiting apoptosis in rats

Phytotherapy Research : PTR
Haiyun LingLianda Li

Abstract

The aim of the present investigation was to evaluate the effect of an extract from Corydalis yanhusuo W.T., a Chinese herbal medicine, on ischemia/reperfusion (I/R) injury and to determine the mechanism(s) involved. In rats, the left anterior descending (LAD) coronary artery was occluded for 30 min and then reperfused for 6 h. 0.5% carboxymethyl cellulose sodium was used as a vehicle (I/R control group) and Corydalis yanhusuo rhizoma extract (I/R + CY 200, 100 mg/kg groups) were given. Infarct size and hemodynamic parameters were measured. Apoptosis was detected quantitatively by the terminal transferase dUTP nick end-labeling (TUNEL) method and confirmed by DNA laddering on agarose gel. The expression of anti-apoptotic Bcl-2 and pro-apoptotic Bax proteins was visualized by western blot analysis. In contrast to the I/R control group, administration with CY 200 mg/kg resulted in a significant reduction in the infarct size and an improvement in heart function as evidenced by higher LVSP and +/-dp/dtmax. TUNEL-positive cells in the ischemic myocardium were also significantly reduced in the I/R + CY 200, 100 mg/kg groups, consistent with little DNA laddering in these two groups. Furthermore, greater Bcl-2 and attenuated Bax express...Continue Reading

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Citations

Dec 4, 2008·The American Journal of Chinese Medicine·Lindsey N JacksonB Mark Evers
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Tae Ho LeeSun Yeou Kim
Nov 30, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Qing LiuDaping Fan
Aug 30, 2007·The Journal of Pharmacy and Pharmacology·Chengping WenLianda Li
Aug 20, 2014·BMC Complementary and Alternative Medicine·Jingjing YanChunhuan Jin
Jun 26, 2017·Journal of Ethnopharmacology·Qiuyue LiYue Shi
Oct 3, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhong-Ze MaDavid Y W Lee
Jan 20, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhiying DouLiu Cao
Feb 1, 2020·Recent Patents on Anti-cancer Drug Discovery·Hongyu TaoXiukun Lin
Apr 1, 2016·Journal of Food and Drug Analysis·Hsin-Yi Hung, Tian-Shung Wu
Apr 1, 2020·Pharmaceutical Biology·Bing TianShu-Ming Huang

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