Abstract
Corynoline, a bioactive compound isolated from Corydalis bungeana Turcz., has been known to have anti-inflammatory activity. However, its effects on the inflammation of the cardiovascular system have not been reported yet. The aim of this study was to investigate the anti-inflammatory effects of corynoline on lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs). The results showed that LPS significantly increased the expression of VCAM-1 and ICAM-1. The production of cytokines TNF-α and IL-8 was also up-regulated by LPS. However, these increases were concentration-dependently suppressed by the treatment of corynoline. To investigate the anti-inflammatory mechanism of corynoline, we checked the activation of NF-κB and the expression of Nrf2. The results showed that LPS-induced NF-κB activation was suppressed by corynoline. The expression of Nrf2 and HO-1 was up-regulated by the treatment of corynoline. Knockdown of Nrf2 could reverse the anti-inflammatory effects of corynoline. In conclusion, the results indicated that corynoline exhibited anti-inflammatory activity by activating Nrf2.
References
Jan 24, 1986·Science·C B Weinberg, E Bell
Feb 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·H LiP Libby
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
May 1, 1997·Immunology Today·A MantovaniM Introna
Aug 29, 1998·Journal of Natural Products·Y Z Shu
Nov 4, 2000·Journal of Periodontology·B G LoosU van der Velden
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Feb 13, 2001·The Journal of Clinical Investigation·T Collins, M I Cybulsky
Nov 16, 2004·Clinical Science·Sieglinde KoflerMichael Weis
Oct 13, 2005·European Heart Journal·Katherine Esposito, Dario Giugliano
May 26, 2007·Nature Reviews. Immunology·Christian WeberElisabetta Dejana
Jun 18, 2009·Expert Opinion on Therapeutic Targets·Jinqing LiTaixing Cui
Mar 27, 2010·Revista da Associação Médica Brasileira·Dimas IkeokaThomas R Pieber
Jun 9, 2015·Free Radical Biology & Medicine·Luciano CominaciniAnna Fratta Pasini
Jan 7, 2016·Ageing Research Reviews·Alejandro Silva-PalaciosCecilia Zazueta
Jan 30, 2016·Oxidative Medicine and Cellular Longevity·Nada Sallam, Ismail Laher
Jul 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chunjuan YangAh-Ng Tony Kong
Sep 13, 2016·Journal of Ethnopharmacology·Xiao-Ting ZhaiFen-Xia Zhu
May 10, 2017·International Immunopharmacology·Yan LiuLixue Huang
Citations
May 21, 2020·Phytotherapy Research : PTR·Chunyang YiXiyun Ye
Sep 27, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Miao TianZhibin Wang
Jan 12, 2021·Phytochemistry·Ai-Ping DengLu-Qi Huang
Nov 17, 2020·Biochemical Pharmacology·Hassan YousefiSuresh K Alahari
May 14, 2021·International Immunopharmacology·Kaiqiang FuRongfeng Cao
Sep 4, 2021·Environmental Toxicology·Yunhao WuJie Chen