Cosmetics and Cancer: Adverse Event Reports Submitted to the Food and Drug Administration

JNCI Cancer Spectrum
Saya L JacobShuai Xu

Abstract

There have been numerous controversies surrounding cosmetic products and increased cancer risk. Such controversies include associations between parabens and breast cancer, hair dyes and hematologic malignancies, and talc powders and ovarian cancer. Despite the prominent media coverage and numerous scientific investigations, the majority of these associations currently lack conclusive evidence. In 2016, the US Food and Drug Administration (FDA) made publically available all adverse event reports in Center for Food Safety and Applied Nutrition's Adverse Event Reporting System (CAERS), which includes complaints related to cosmetic products. We mined CAERS for cancer-related reports attributed to cosmetics. Between 2004 and 2017, cancer-related reports caused by cosmetics represented 41% of all adverse events related to cosmetics. This yielded 4427 individual reports of cancer related to a cosmetic product. Of these reports, the FDA redacted the specific product names in 95% of cancer-related reports under the Freedom of Information Act exemptions, most likely due to ongoing legal proceedings. For redacted reports, ovarian cancer reports dominated (n = 3992, 90%), followed by mesothelioma (n = 92, 2%) and malignant neoplasm unspeci...Continue Reading

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Citations

Jan 17, 2020·International Journal of Environmental Research and Public Health·Rama NatarajanVictoria L Seewaldt
Jan 15, 2021·Clinical, Cosmetic and Investigational Dermatology·Nazeer Hussain KhanXin-Ying Ji

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Methods Mentioned

BETA
acetylation

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