Cost analysis of secondary prophylaxis with oral clodronate versus pamidronate in metastatic breast cancer patients

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Dorothy RomanusThomas R Einarson

Abstract

We compared the direct medical costs of secondary prophylaxis with bisphosphonates (BPs) in bone metastases (BMs) of breast cancer (BCa) from a payer perspective. This study adopted an incidence-based chart review of consecutive BCa patients with BMs who received prophylactic treatment with orally administered (po) clodronate (CLODpo group), or intravenously administered (iv) pamidronate (PAM group) in 1997 at two large oncology centers in Toronto, Ontario. We evaluated the difference in costs of management of patients among the CLODpo and PAM groups using an intent-to-treat analysis from diagnosis of BMs to death, or last follow-up. The results are presented as observed mean and average lifetime (including terminal care) costs per patient. The observed mean costs in the PAM and CLODpo groups were 49,472 dollars and 50,307 dollars (2002 Canadian dollars), respectively. The difference in costs between the CLODpo (n=34) and PAM (n=18) groups was not significant (P=0.64), and remained robust after sensitivity analyses. The corresponding average lifetime costs were 65,677 dollars in the CLODpo group and 61,254 dollars in the PAM group. Inpatient and terminal care were the major cost drivers, comprising 45% and 25% of overall costs....Continue Reading

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Citations

May 6, 2005·Journal of Vascular and Interventional Radiology : JVIR·Daniel B Brown
Dec 6, 2005·Archives of Gerontology and Geriatrics·Antonino SantangeloDomenico Maugeri
Sep 8, 2015·Clinical & Experimental Metastasis·Caterina FontanellaFabio Puglisi
Oct 9, 2013·Anti-cancer Drugs·Ana LluchJosé-Alejandro Pérez-Fidalgo

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