Cost avoidance related to a pharmacist-led pharmacogenomics service for the Program of All-inclusive Care for the Elderly.

Pharmacogenomics
Kevin T BainAdriana Matos

Abstract

Aim: Estimate cost avoidance of pharmacist recommendations for participants enrolled in the Program of All-inclusive Care for the Elderly. Materials & methods: Convenience sample of 200 pharmacogenomics consultations from the PHARM-GENOME-PACE study. Genetic variants, drug-gene interactions, drug-drug-gene interactions and phenoconversions were interrogated. Cost avoidance was estimated and adjusted for inflation. Results: In total, 165 participants had at least one actionable drug-gene pair totaling 429 drug-gene pairs, of which 158 (36.8%) were clinically actionable. Most (70.5%) pharmacists' recommendations were accepted. Estimated cost avoidance was $233,945 when all recommendations were included but conservatively $162,031 based on acceptance rates. Overall mean cost avoidance per actionable drug-gene pair was $1063 or $1983 per participant. Conclusion: Pharmacist-led pharmacogenomics services added to the traditional medication review can avoid substantial costs for payers. Clinical trial registration number: NCT03257605.

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Citations

Jul 13, 2020·Clinical Transplantation·Kimberly M DeiningerChristina L Aquilante
Jul 23, 2021·Pharmacogenomics and Personalized Medicine·Susanne B HagaDeepak Voora
Sep 4, 2021·Research in Social & Administrative Pharmacy : RSAP·Meagan HayashiSherif Hanafy Mahmoud
Oct 3, 2021·Human Genetics·Evangelia Eirini TsermpiniGeorge P Patrinos

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Methods Mentioned

BETA
genotyping

Clinical Trials Mentioned

NCT03257605

Software Mentioned

GENOME
PHARM
PACE

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