PMID: 2110651Apr 1, 1990Paper

Cost-benefit analysis of Haemophilus influenzae type b prevention: conjugate vaccination at eighteen months of age

The Pediatric Infectious Disease Journal
J W Hay, R S Daum

Abstract

A cost-benefit analysis of Haemophilus influenzae type b disease preventive strategies was updated to consider evaluation of the H. influenzae type b polysaccharide-diphtheria toxoid conjugate vaccine (PRP-D) and H. influenzae type b oligosaccharide-mutant diphtheria toxin conjugate vaccine (HbOC) for children at 18 months of age. The analysis was done from the perspective of society as a whole. The economic costs of H. influenzae type b disease in the 1988 United States birth cohort would be $2.546 billion (1988 U.S. dollars) in the absence of preventive efforts. If 60% of all children could be vaccinated with PRP-D or HbOC at 18 months of age, this strategy would save $207.1 million ($88.22 savings/vaccinee; $43,605 cost/case prevented; 3.57/1 benefit-to-cost ratio) under base case model assumptions. Universal PRP-D or HbOC vaccination at 18 months of age would prevent 1845 cases of invasive H. influenzae type b disease. The break-even efficacy for universal PRP-D or HbOC vaccination at 18 months of age was 22.7%. We conclude that, under the model base case assumptions, universal PRP-D or HbOC vaccination at 18 months of age is sufficiently efficacious so that the costs of vaccination would be more than offset by decreased me...Continue Reading

Citations

Jan 1, 1994·Scandinavian Journal of Infectious Diseases·B Trollfors
Jul 22, 1998·Scandinavian Journal of Infectious Diseases·O GarpenholtL A Levin
Jul 25, 2017·Journal of Medical Economics·Bunchai ChongmelaxmeNathorn Chaiyakunapruk
Dec 1, 1995·Journal of Travel Medicine·M E Wilson
Jan 27, 2004·The Pediatric Infectious Disease Journal·Regina BrinsmeadDamian Walker
Jun 19, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Kenneth W PurdyJoel I Ward
Apr 20, 1992·The Medical Journal of Australia·G L Gilbert

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