Cost-effective osteoporosis treatment thresholds in Greece

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
P MakrasG P Lyritis

Abstract

A Greek-specific cost-effectiveness analysis determined the FRAX-based intervention thresholds. Assuming a willingness to pay of 30,000 <euro>, osteoporosis treatment is cost-effective in subjects under the age of 75 with 10-year probabilities for hip and major osteoporotic fractures of 2.5 and 10 %, respectively, while for older patients, the same thresholds are raised to 5 and 15 %. The purpose of this study was to determine the FRAX calculated fracture probabilities at which therapeutic intervention can be considered as cost-effective in the Greek setting. A Markov cohort model was populated with Greek data, and quality-adjusted life years (QALYs) were used to calculate the cost-effective thresholds for an annual medication cost of 733.7 <euro> by gender and age. Average FRAX-based 10-year probabilities for both major osteoporotic and hip fractures were multiplied by the model-derived relative risk at which a cost of 30,000 <euro> for each QALY gained was observed for treatment versus to no intervention. A biphasic intervention threshold model is supported by our findings. Osteoporosis treatment becomes cost-effective when absolute 10-year probabilities for hip and major osteoporotic fractures reach 2.5 and 10 %, respectivel...Continue Reading

References

Nov 5, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·John A KanisBengt Jonsson
Sep 29, 2004·Home Health Care Services Quarterly·Thomas W Gantert, Carol L McWilliam
Nov 10, 2006·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·N ZethraeusB Jönsson
Dec 6, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Russel BurgeAnna Tosteson
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A N A TostesonUNKNOWN National Osteoporosis Foundation Guide Committee
Feb 23, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S FujiwaraJ A Kanis
Jun 12, 2008·The Journal of Clinical Endocrinology and Metabolism·Bess Dawson-Hughes, UNKNOWN National Osteoporosis Foundation Guide Committee
Aug 30, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN National Osteoporosis Guideline Group
Jan 13, 2009·Maturitas·J CompstonUNKNOWN National Osteoporosis Guideline Group (NOGG)
Jun 12, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K LippunerR Rizzoli
Oct 14, 2010·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Alexandra PapaioannouUNKNOWN Scientific Advisory Council of Osteoporosis Canada
Aug 24, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S R Majumdar
Jan 10, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K LippunerR Rizzoli
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·David M EddyUNKNOWN ISPOR−SMDM Modeling Good Research Practices Task Force
Oct 16, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·G P LyritisP Makras
Dec 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O StrömJ A Kanis
Oct 12, 2013·Archives of Osteoporosis·A SvedbomUNKNOWN EU Review Panel of IOF
Sep 4, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F CosmanR Lindsay

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Citations

Mar 27, 2016·Calcified Tissue International·Andréa MarquesJosé António P da Silva
Jul 29, 2016·Archives of Osteoporosis·John A KanisUNKNOWN Advisory Board of the National Osteoporosis Guideline Group
Sep 22, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M ChakhtouraG El-Hajj Fuleihan
Nov 23, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L CuiW Xia
Dec 23, 2016·Archives of Osteoporosis·Polyzois MakrasGeorge P Lyritis
Oct 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J A KanisUNKNOWN Scientific Advisory Board of the European Society for Clinical and Economic Aspects of Osteoporosis (ESCEO) and the Committe
Mar 17, 2019·Archives of Osteoporosis·Polyzois MakrasChristos Kosmidis
Jan 4, 2020·Archives of Osteoporosis·Polyzois MakrasChristos Kosmidis
Oct 18, 2020·Archives of Osteoporosis·Athanasios D Anastasilakis, Polyzois Makras
May 1, 2021·Biomedicines·Maria P YavropoulouDimitrios Chatzidimitriou

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