Cost-effective smartphone-based reconfigurable electrochemical instrument for alcohol determination in whole blood samples

Biosensors & Bioelectronics
Joan AymerichMichele Dei

Abstract

The determination of ethanol intoxication in whole blood samples may open the opportunity for a precise and quick point-of-measurement in the ambit of medical emergency or law enforcement. In contrast with traditional techniques based on breath sampling, direct blood measurements present greater immunity to errors specially in case of unconscious or non-collaborative patients. In this context, a portable, sensitive and easy-to-use instrument is highly desirable. In the current work we present a smartphone-based µPotentiostat which combines a novel circuital technique for sensor readout digitalization with a reusable lab-on-a-chip (LoC) concept. Such system allows both chronoamperometric and cyclic voltammetry measurements with a reduced number of electronic components on a very compact PCB (38.5 × 22.5 mm2). Power, data-link and user interface are provided in combination with a standard smartphone, enabling cost-effectiveness and reconfigurability without sacrificing precision. The readout platform discussed in this work has been coupled to a LoC for point-of-care combining Pt electrodes microfabricated on silicon substrate for electrochemical measurement and a microfluidic structure of methacrylate for fluid management. Biosen...Continue Reading

Citations

Jan 17, 2020·Electrophoresis·Wenhao ZhaoLijuan Dong
Mar 5, 2020·Lab on a Chip·Fumihiro SassaHiroaki Suzuki
Nov 2, 2019·Biosensors·Paloma Yáñez-SedeñoJosé Manuel Pingarrón
Dec 11, 2019·Sensors·Yaiza Montes-CebriánPere Ll Miribel-Català
May 24, 2020·Polymers·Kamila SpychalskaJoanna Cabaj
Jan 1, 2021·Talanta·Julien BiscayLynn Dennany

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