Cost-effectiveness analyses using real-world data: an overview of the literature

Journal of Medical Economics
Kevin BowrinMondher Toumi

Abstract

Objectives: Real-world evidence (RWE) may provide good estimates of absolute event probabilities and costs in patients in actual clinical practice, but their use in decision-analytic models poses many challenges. A literature review based on a systematic search was conducted to summarize the limitations of using RWE in decision-analytic modeling reported in the literature, but also to identify existing recommendations about real-world modeling. Methods: A literature search was performed on Medline and Embase databases, as well as relevant websites. No restrictions in language or geographical scope were imposed. Results: A total of 14 references were included. RWE is recognized as a valuable source of data for market access and reimbursement, and as a complement to clinical trial evidence for treatment pathways, resource use, long-term natural history, and effectiveness. The main limitations identified in the literature were: confounding bias, missing data, lack of accurate data related to drug exposure and outcomes, errors during the record-keeping process, protection of private data, and insufficient numbers of patients. Although most submission guidelines recognized the potential biases associated with RWE, guidance on the ap...Continue Reading

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Citations

Feb 16, 2020·International Journal of Environmental Research and Public Health·Elizabeth Parody-RúaIgnacio Aznar-Lou
Jul 14, 2020·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Eric P Borrelli, Conor G McGladrigan
Jul 14, 2020·Journal of Medical Economics·Kevin BowrinAurélie Millier
Apr 27, 2021·International Journal of Technology Assessment in Health Care·Benedetta PongiglioneMike Drummond
Aug 6, 2021·Open Access Rheumatology : Research and Reviews·Ilaria Bertoldi, Roberto Caporali
Aug 5, 2021·Applied Clinical Informatics·Vojtech HuserCraig S Mayer

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