PMID: 7540297Jun 1, 1995Paper

Cost-effectiveness analysis in early detection of prostate cancer: an evaluation of six screening strategies in a randomly selected population of 2,400 men

The Prostate
O GustafssonH Svensson

Abstract

Based on the findings in an early detection study for prostate cancer [Gustafsson et al.: J Urol 148:1827-1831, 1992] using digital rectal examination (DRE), transrectal ultrasound (TRUS), and prostate-specific antigen (PSA), a cost-effectiveness analysis was performed based on 6 screening strategies, namely: 1) DRE of all individuals; 2) TRUS of all individuals; 3) DRE, TRUS, and PSA analysis followed by reexamination of individuals with PSAs > or = 7 ng/ml; 4) DRE of individuals with PSAs of > or = 4 ng/ml; 5) TRUS of individuals with PSAs of > or = 4 ng/ml; 6) DRE and PSA analysis followed by TRUS on individuals with PSAs > or = 4 ng/ml. The detection rates of prostate cancer using these 6 strategies were 2.4%, 3.3%, 3.6%, 2.0%, 2.6%, and 3.2%, respectively. Except for costs per detected cancer, costs were also calculated per detected small cancer (< or = 1.5 cm) and per detected cancer treated for cure. The cost calculations were based on total costs, i.e., direct plus indirect costs. When the 6 strategies were compared, taking into account the detection rate of cancers treated for cure and cost-effectiveness with respect to cancers treated for cure, strategies 1), 2), 3), and 4) were ruled out as less favorable than the re...Continue Reading

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Citations

May 21, 2011·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Fernando AntoñanzasM Pinillos
Jun 25, 1998·European Journal of Radiology·C C Blackmore, W J Smith
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Jul 21, 2012·Expert Review of Pharmacoeconomics & Outcomes Research·Afschin Gandjour
Jun 15, 2013·Expert Review of Pharmacoeconomics & Outcomes Research·Vishvas GargDennis W Raisch
Dec 13, 2006·Radiologic Clinics of North America·Oguz Akin, Hedvig Hricak
May 9, 2003·The Urologic Clinics of North America·Rajveer S PurohitPeter R Carroll
Feb 13, 2015·Future Oncology·Chunhuan LaoRoss Lawrenson
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May 25, 2004·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Deuk Jae SungDu Geon Moon

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