Cost-Effectiveness Analysis of an Adherence-Promotion Intervention for Children With Leukemia: A Markov Model-Based Simulation

Journal of Pediatric Psychology
Meghan E McGradyAhna L H Pai

Abstract

Improving medication adherence among children with B-cell precursor acute lymphoblastic leukemia (B-ALL) has the potential to reduce relapse rates but requires an investment in resources. An economic evaluation is needed to understand the potential costs and benefits of delivering adherence-promotion interventions (APIs) as part of standard clinical care. A Markov decision analytic model was used to simulate the potential incremental cost-effectiveness per quality-adjusted life year (QALY) to be gained from an API for children with B-ALL in first continuous remission compared with treatment as usual (TAU, no intervention). Model parameter estimates were informed by previously published studies. The primary outcome was incremental cost (2015 US$) per QALY gained for API compared with TAU. The model predicts the API to result in superior health outcomes (4.87 vs. 4.86 QALYs) and cost savings ($43,540.73 vs. $46,675.71) as compared with TAU, and simulations indicate that, across a range of plausible parameter estimates, there is a 95% chance that the API is more effective and less costly than TAU. The API was estimated to remain more effective and less costly than TAU in situations where the prevalence of nonadherence exceeds 32% ...Continue Reading

References

Oct 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·F A Sonnenberg, J R Beck
May 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R BarrM Brain
Oct 16, 1996·JAMA : the Journal of the American Medical Association·M C WeinsteinL B Russell
May 1, 1997·Health Economics·M J BuxtonM Vray
Sep 8, 2000·PharmacoEconomics·A Brennan, R Akehurst
Feb 24, 2006·Health Economics·Mark J SculpherChris McCabe
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julio C BarredoA Kim Ritchey
Oct 28, 2006·PharmacoEconomics·Milton C Weinstein
Jan 15, 2008·Health Policy·Oya Eddama, Joanna Coast
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth A RaetzWilliam L Carroll
Dec 20, 2008·Journal of the American College of Cardiology·David J Cohen, Matthew R Reynolds
Mar 11, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Milton C WeinsteinAlistair McGuire
Oct 21, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard H KoMignon L Loh
Mar 30, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yu-Feng LinRobert A Krance
Apr 9, 2011·BMJ : British Medical Journal·Stavros Petrou, Alastair Gray
May 9, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Smita BhatiaF Lennie Wong
Sep 20, 2012·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Uwe SiebertKaren M Kuntz
Mar 30, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Don HusereauUNKNOWN ISPOR Health Economic Evaluation Publication Guidelines-CHEERS Good Reporting Practices Task Force
May 10, 2013·Journal of Pediatric Psychology·Yelena P WuEmily M Fredericks
Jun 19, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cornelia EckertArend von Stackelberg
Jul 28, 2013·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Raphaële R L van LitsenburgReinoud J B J Gemke
Jan 8, 2014·European Journal of Cancer Care·C RaeR Barr
Jul 6, 2014·Journal of Pediatric Psychology·Tonya M Palermo
Oct 16, 2014·The New England Journal of Medicine·Shannon L MaudeStephan A Grupp
Apr 18, 2015·Bulletin of the World Health Organization·Elliot MarseilleSydney Rosen
Aug 11, 2015·Child: Care, Health and Development·M E McGradyA L H Pai
Oct 16, 2015·The New England Journal of Medicine·Stephen P Hunger, Charles G Mullighan
Oct 24, 2015·Haematologica·Trausti OskarssonUNKNOWN Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL relapse working group
Dec 25, 2015·Pediatric Blood & Cancer·Ahna L H Pai, Meghan E McGrady
Jan 27, 2016·Psycho-oncology·Mbathio DiengRachael L Morton

❮ Previous
Next ❯

Citations

Feb 25, 2020·International Review of Psychiatry·Carisa ParrishRick Ostrander
Aug 28, 2020·Journal of Pediatric Hematology/oncology·Akshat Jain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.