Cost-Effectiveness Analysis of Demineralized Bone Matrix and rhBMP-2 versus Autologous Iliac Crest Bone Grafting in Alveolar Cleft Patients

Plastic and Reconstructive Surgery
Sagar MehtaFaizi Siddiqi

Abstract

The standard of care for patients with alveolar cleft deformities is autologous bone grafting using iliac crest bone graft (ICBG). The combination of demineralized bone matrix with recombinant human bone morphogenetic protein-2 (DBX/rhBMP-2), as a substitute for ICGB, has been shown to have similar bony incorporation within the maxilla without donor-site morbidity. It has been argued that one of the drawbacks of using DBX/rhBMP-2 is the higher cost. The aim of this study was to compare the cost, operative time, and hospital length of stay associated with these two treatment modalities. A chart review was conducted for 71 patients who underwent secondary alveolar cleft reconstruction. Forty patients received ICBG and 31 patients underwent reconstruction using DBX/rhBMP-2. Operative costs, operative time, and hospital length of stay were compared between the two groups. The average total operative cost was $6892 in the ICBG surgery population versus $4836 in the DBX/rhBMP-2 population (p < 0.01). Statistically significant decreases in anesthesia, pharmacy, and operating room costs were found in patients who underwent the DBX/rhBMP-2 surgery. Operative time decreased from an average of 97.3 minutes to 67.0 minutes (p < 0.01), and ...Continue Reading

References

Mar 1, 1991·Plastic and Reconstructive Surgery·M CohenH Aduss
Jun 1, 1984·Plastic and Reconstructive Surgery·S W LaurieJ E Murray
Jun 14, 2000·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·H Eufinger, H Leppänen
Jan 13, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Ananth S Murthy, James A Lehman
Aug 19, 2005·The British Journal of Oral & Maxillofacial Surgery·Y L JiaL Ma
Jan 8, 2008·Plastic and Reconstructive Surgery·Brian P DickinsonJames P Bradley
Aug 21, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Massimo FasolisGuglielmo Ramieri
Feb 7, 2013·Plastic and Reconstructive Surgery·Cameron S FrancisJeffrey A Hammoudeh

❮ Previous
Next ❯

Citations

Jan 10, 2019·Journal of Clinical Periodontology·Siddharth ShanbhagKamal Mustafa
Nov 9, 2019·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Francisca UribeRodrigo Fariña
Jul 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Zhuo LiangYonggang Lv
Nov 16, 2020·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kevin C LeeMichael A Perrino
Jan 15, 2021·International Journal of Environmental Research and Public Health·Jhonathan R B NascimentoJosé A Calasans-Maia
Jul 3, 2021·Bioengineering·Inês FranciscoFrancisco Vale

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.