Cost-effectiveness analysis of intensity-modulated radiation therapy with normal and hypofractionated schemes for the treatment of localised prostate cancer

European Journal of Cancer Care
A T ZemplényiL Mangel

Abstract

The aim of our analysis was to compare the cost-effectiveness of high-dose intensity-modulated radiation therapy (IMRT) and hypofractionated intensity-modulated radiation therapy (HF-IMRT) versus conventional dose three-dimensional radiation therapy (3DCRT) for the treatment of localised prostate cancer. A Markov model was constructed to calculate the incremental quality-adjusted life years and costs. Transition probabilities, adverse events and utilities were derived from relevant systematic reviews. Microcosting in a large university hospital was applied to calculate cost vectors. The expected mean lifetime cost of patients undergoing 3DCRT, IMRT and HF-IMRT were 7,160 euros, 6,831 euros and 6,019 euros respectively. The expected quality-adjusted life years (QALYs) were 5.753 for 3DCRT, 5.956 for IMRT and 5.957 for HF-IMRT. Compared to 3DCRT, both IMRT and HF-IMRT resulted in more health gains at a lower cost. It can be concluded that high-dose IMRT is not only cost-effective compared to the conventional dose 3DCRT but, when used with a hypofractionation scheme, it has great cost-saving potential for the public payer and may improve access to radiation therapy for patients.

References

Jul 20, 2002·International Journal of Radiation Oncology, Biology, Physics·Alan PollackIsaac Rosen
Apr 6, 2004·Journal of General Internal Medicine·Robert J VolkMurray D Krahn
Feb 17, 2005·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Imre BonczLászló Korösi
Mar 22, 2005·Medical Care·Susan T StewartRobert M Kaplan
Oct 26, 2005·International Journal of Radiation Oncology, Biology, Physics·Alan PollackRobert A Price
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stephanie T H PeetersJoos V Lebesque
Nov 9, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Murray KrahnGary Naglie
Feb 13, 2007·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Patrick W SullivanDarryl Sleep
Mar 4, 2008·International Journal of Radiation Oncology, Biology, Physics·Michael J ZelefskyHoward I Amols
Jul 21, 2009·International Journal of Radiation Oncology, Biology, Physics·Gustavo Arruda VianiSergio Luis Afonso
Jan 6, 2010·International Journal of Radiation Oncology, Biology, Physics·Giorgio ArcangeliLidia Strigari
Apr 1, 2010·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Martin DolezelIgor Hartmann
May 25, 2010·International Journal of Radiation Oncology, Biology, Physics·Deborah A KubanAlan Pollack
Jun 8, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·G BaumanUNKNOWN Members of the IMRT Indications Expert Panel
Jun 19, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·J H E YongJ S Hoch
Aug 31, 2012·ISRN Oncology·Despina Spyropoulou, Dimitrios Kardamakis
Sep 13, 2012·Acta Oncologica·Alexandru Dasu, Iuliana Toma-Dasu
Mar 5, 2013·Cancer Treatment Reviews·Nicholas G ZaorskyRobert B Den
Oct 9, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alan PollackMark K Buyyounouski
Feb 18, 2014·Clinical Oncology : a Journal of the Royal College of Radiologists·A C TreeM Partridge
Mar 26, 2014·International Journal of Radiation Oncology, Biology, Physics·Karen E HoffmanDeborah A Kuban
Aug 31, 2014·European Urology·Bridget F KoontzAnthony D'Amico
Nov 5, 2014·Expert Review of Anticancer Therapy·Fabio Ynoe de MoraesRafael Gadia
Jan 1, 2013·Value in Health Regional Issues·Zoltán KalóUNKNOWN ISPOR Hungary Chapter

❮ Previous
Next ❯

Citations

Mar 18, 2016·Cancer Treatment Reviews·Cyrus ChargariEric Deutsch
Nov 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Hester LiengCharles Catton
Mar 14, 2018·Journal of Medical Radiation Sciences·Darren HunterNigel Anderson
Oct 12, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott C MorganHoward Sandler
Mar 15, 2016·Orvosi hetilap·Antal Tamás ZemplényiImre Boncz
Apr 27, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Hideki MurasawaKojiro Shimozuma
May 13, 2017·Frontiers in Oncology·David AzriaBarry S Rosenstein
Apr 2, 2020·Radiation Oncology Journal·Sang Hoon JungWon Park
Aug 14, 2020·The British Journal of Radiology·Leif-Erik D SchumacherEric A Mellon
Mar 15, 2018·Journal of Radiation Research·Thomas J WhitakerRobert L Foote
Nov 9, 2018·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Elke RammantValérie Fonteyne
Jul 31, 2019·Current Urology Reports·Soumyajit Roy, Scott C Morgan
Jul 17, 2020·Frontiers in Oncology·Victor R Adorno FeblesDavid R Wise
Aug 5, 2019·International Journal of Radiation Oncology, Biology, Physics·Giulia MarvasoBarbara A Jereczek-Fossa
Aug 15, 2021·Nature Reviews. Urology·Michael YanFabio Y Moraes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.